保健 - 第81期 - page 39

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專題探索
९eЄḩe҇აર̈ᄣ̋f2/ ிϓ৶ሯଯᕦfΪί˾
ᑽପي ર̈ᄣ̋ٙΝࣛdඑٙર̈ɰึᄣεdிϓ
එٙ ݴ̰f3/ Ⴐ೯ːА၍शषfΪЂᗳў৷ཱིձইٴ
აձᑔոቐf 4/Ⴐ೯ᐖसf̙Ⴐ೯Ԫ໗ᐖeٜ໑ᐖe
ഥᐖഃf
ɚe͍ᆽႩᗆஐͣሯ ڭ਄ۜٙᄆ࠽
ࠅ ͍ᆽႩᗆஐͣሯ ڭ ਄ۜٙॆ͍ᄆ ࠽ d̀඲ə༆ஐ
ͣሯίɛ᜗lzऊʷձіϗٙཀ೻f࠮ ي ʕٙஐͣሯ
ආɝܝߞdึ஗ ߞ ஐͣ㺛ʲᓙdϓ މ ೵ٙᗡdவԬ
ᗡආɝʃ໑ ܝ dաՑঈஐͣ㺛ձ໑㹻㺛ٙऊʷd௰
ܝ ஗ʱ༆ϓऄਿაf್ ܝ Ԓ᜗Ύਗ਼ऄਿა˜ᎇዚ™
Υϓ΢၇ც ࠅ ٙஐͣሯf ה ˸dԨʔ݊Φɝ ၇ݔஐ
ͣሯd̴ʱ༆ ܝ ٙऄਿაdఱɓ֛ึ͜ԸΥϓࡡԸ
ԟ၇ஐͣሯfһʔ݊Φɝ ࡈݔ௅Зٙஐͣሯdఱࡡ
܆ʔਗήd͊຾ऊʷdఱ஽ٜൺՑࡡԸ ࡈݔ௅Зɪ
Ըٙf
ɧeܔ ͭ৕ྤߗ ա׌d౤৷࿁৕ྤٙߗ աঐɢ
৕ྤஐͣձʱɿМ گ dɚ٫ٙ̌ঐਿ͉݊ɓᅵٙd
ே݊ஐͣሯٙ˜ၪ ࡌ ࡰ™f̥ʔཀί̻੬ً࿒ɨႡ
ி̈ԸੂБ΂ਕ̣ٙʱɿМ گ dίڢ ̻੬ً࿒dν
೯ᆠeॹАഃ৕ྤɨdҞ஺Ⴐኬ̈Ըٙdఱ̣৕ྤ
ஐͣfՇ၇ஐͣሯேϞཫԣ୚ ߤ lzஐͣሯኑණٙ̌
ঐdϾ˲dϞԬʱɿМگ dν HSP70eHSP104 ᒔ̙
˸ਗ਼ʊኑණٙஐͣሯʱ༆f
Ϟ޼Ӻ೯ତdίቇ຅ࣛගٙ৕ྤɨ€νॹАd̙
Ⴐኬ̈৕ྤஐͣdவԬஐͣਗ਼Դዚ᜗һঐ ߗ աᘱʘ
ϾԸһ ڗ ࣛගॹАٙฦෆdவ၇ତ൥၈ މ ৕ྤߗ ա
׌f޼Ӻ٫Ⴉ މ dϤᑘਗ਼ϞૐᏐ͜׵໘ॹАձኜ
֜ٙ୅ಔf˼ ࡁ ੽ਗي €ཽٙኜ֜୅ಔ޼Ӻʕ೯
ତd຅ኜ֜͊੽͛᜗࿜ɨ ۃ d߰΋݄˸ᆠ;дdႰ
ኬ৕ྤஐͣሯٙ͛ϓdʘ ܝ dΎҪኜ֜࿜ৰdவ࿁
Չ ܝ d୅ಔ ۃ ɓ ݬ ࣛග୅ಔኜ֜ΪॹАϾˏߧ ٙฦ
ෆϞڭᚐЪ͜dϞп׵୅ಔٙϓ̌f
̬e೯౨ʱɿМگ ࿁शषԣطٙЪ͜
ν ࠑהۃ d྅ڛ ဧভऎᎰषe౷ΪஐЈषഃशषd
Չ΍ΝዚՓே݊͟׵ஐͣሯٙʔ͍੬ұ䂓ˏߧ ٙኑ
ණձᜊ׌d ߧם୚ ߤ ٙฦෆdΪϤdઞరႰኬत֛
ٙʱɿМ گ dҵՓவԬஐͣሯٙኑණ೯͛d̙ૐϓ
މ ԣ ط வᗳशषٙอ༩ΣfϤ̮dɰϞ޼Ӻ٫͍੽
ԫЭʱɿʷΥ ي ٙ޼ӺdΆྡҬ̈ቇΥٙʷΥي d
Դʘၾत֛ٙኑණஐͣሯഐΥdԸԣ˟Չኑණٙ
೯͛fరҬႰኬʱɿМ گ ٙʕᖹdਗ਼ึഗʕᖹٙ޼
Ӻdකן อٙ༩Σf
ʞeరҬ࿁Ҥƺ-ዠ४ᅵஐͣݭ ׌ٙيሯ
రҬ࿁Ҥዠ४ᅵஐͣ ݭ ׌ٙي ሯd࿁ԣ ط ɓԬ͟׵
ƺ -ዠ४ᅵஐͣମ੬Ӑጐ੭Ըݭ ׌Ъٙ͜शषdɰ݊
ɓ ࡈࠠ ࠅ ٙઞ॰˙Σfኽజ༸d2010ϋ4 ˜ᅃ਷ɓධ
௰อ޼Ӻϓ ؈ ᜑͪdၠ঩ٙ ݺ ׌ ي ሯ˜ڌ Ӛ࠮ɿՅ
঩९Ӛ࠮ɿა◐€EGCG™̙༆ৰၾڛဧভऎᎰष
ഃशषϞᗫٙஐͣሯମ੬Ӑጐ੭Ըٙ ݭ ׌f޼Ӻ٫
ί༊၍ձ୚ߤ ੃ቮਿྼ᜕ʕ೯ତ: ˜ಔɝவ၇Ϟݭஐ
ͣሯdึኬ ߧ ग़຾୚ ߤ อ௓˾ᑽ˥̻ɨࠥd୚ߤ ᇫ
ɰึᜊ੻ʔᖢ֛dϾɓ͇̋ɝၠ঩ݺ׌ يሯ EGCGd
வԬ୚ߤաฦٙତ൥ఱึऊ̰f޼Ӻ٫Ⴉމ dEGCG
ݭ༆ Ъٙ͜ዚՓ݊Չ࠯΋ၾƺ-ᜄၪًዠ४ᅵஐͣഐ
Υdਗ਼ ٫ܝᔷᜊϓ࿁ग़຾୚ ߤ ೌ࢔eʘ ܝ ɦึ஗୚
ߤʱ༆ٙଢًஐͣၳΥ᜗f™
Proteins and Our Health
Proteins are made of 20 different amino acids; peptides, with their shorter chains, often adopt 3-D structures in coils or in folds
like saw teeth – all very important functionally. Folding requires companions: “chaperonin” and “heat shock proteins”, e.g.,
Hsp70. When folding is abnormal, proteins coagulate, are denatured and accumulate inside the cell causing diseases or even
death. Alzheimer’s disease – one of the commonest types of senile dementia, arises from the accumulation of a β-amyloid
protein in the brain to form amyloid plaques and neurofibrillary tangles. Gradually, normal brain function goes; senile dementia
results. Thus, β-amyloid protein is the “culprit” for Alzheimer’s disease. Another misfolded protein called “prions” is the
infectious agent in “mad cow disease” – causing the brain to have holes under the microscope, just like a sponge; there is
degeneration of physical and mental abilities and ultimately death. As beef may also be contaminated and that prions are
resistant to heat, never take any such beef, no matter how well cooked they are. Recently, there is hope that EGCG from green
tea may tackle such misfolded proteins.