保健 - 第104期 - page 53
專題探索
53
IL-17
ၾ
ف
सˀᏐ
IL-17
݊ͦ
ۃ
อ೯ତٙ˴
ࠅ
͟াኳ
T
ߤ
ʱ
ؤ
ٙɓ၇
فڮ
ߤ
ΪɿfՈϞ੶ɽ
ם
ʕ
ߤ
ٙঐɢe
ɦঐ
ڮ
ආε၇
ߤ
ᙑ׳
ف
Ϊɿf˴
ࠅ
ܼ̍
IL-1
e
IL-6
e
IL-8
e
IL-23
e
TNF
ձ
IFN-r
ഃf݊ɓᗳอۨͣ
ʧ९d࿁
ف
सٙ೯͛೯࢝ৎഹʔׁ̙ൖٙЪ͜f
߅ኪʃཽٙ
T
ߤ
ˋᆯ
ߤ
ʕ೯ତə
IL-
17A
dԨ೯ତίਿΪଡ଼ʕᒔўϞՉ˼ʞ
ࡈ
ձ
IL-17A
Ν
๕ٙਿΪd͟Ϥdɛ
ࡁ
ਗ਼ʬ
ࡈ
Ν๕ٙ
ߤ
Ϊɿᓥɝ
ɓ
ࡈ
อٙ
IL-17
ૄdʱйնΤ
މ
IL-17A
Ց
IL-17F
f
ΝࣛdᒔҬՑ̴
ࡁ
ٙաૄfவԬʔΝٙ
IL-17
̙
˸ഐΥ࿁ᏐٙաdϾʧኬʔΝٙ
ف
सˀᏐf
Ցͦ
೯ۃ
ତՉၾዚε၇शषᗫfतй݊ၾ٬
ช
ݑ
eࡲఁeᗳࠬ᐀ᗫື
ف
eኜ֜ಔe໑༸
ف
सഃ
ف
सशषϞᗫf
IL-10
ၾ໕ᆯ
IL-10
݊ɓ၇˴
ࠅ
ࣖ͟Ꮠ
T
ߤ
ପ͛ٙе
ޥ
ሜືΪɿd
݊ՈϞе
ޥ
ҵՓЪٙ͜Ҥ
ف
ʱɿf
ڐ
ϋԸٙӺ೯
ତ
IL-10
࿁໕ᆯ̙ঐ೯౨ᕐΣٙе
ޥ
ሜືЪ͜fу݅
̙
ڮ
ආ໕ᆯ͛
ڗ
dɦ̙ҵՓ໕ᆯ೯͛೯࢝ձᔷf
IL-10
ঐ
ڮ
ආ໕ᆯ͛
ڗ
݊Ϊ
މ
I/
ٜટҵՓࣖᏐ
T
ߤ
ᄣ
ಟձቋঐɢԨɨሜᗫΪɿٙପ͛f
2/
ஷཀҵՓҤ
ࡡя
ߤ
ٙ
ݺ
ʷЪ͜dପ͛࿁
T
ߤ
ٙҵՓࣖᏐԸ
Җϓе
ޥ
ҵՓᐑྤdϾႰኬ໕ᆯе
ޥ
අf
ה
˸d
IL-10
˥̻৷ࣛd
T
ߤ
࿁໕ᆯ
ߤ
ٙ૨ෆࣖᏐ
ᜑҵՓf
IL-10
ɦঐԴ໕ᆯҵՓ݊Ϊ
މ
̴ঐ
1/
̙˸ҵՓ
TH17
ߤ
e̶አ
ߤ
ʿ
IL-23
ഃ
ڮ
ආ໕ᆯ೯͛೯࢝ٙ
ف
Ϊ
ɿdආϾҵՓ໕ᆯᗫ
ف
सd৷ዚҤ໕ᆯЪ͜i
2/
̙˸ٜટ
א
ගટ
ݺ
ʷ
NK
ߤ
ձ໕ᆯत៦
CD8+T
ߤ
Ԩ৷Չ
ݺ
dϾ৷ዚ࿁໕ᆯٙ૨ෆࣖ
ᏐdҵՓ໕ᆯٙ೯࢝ձᔷf
IL-10
வ၇࿁໕ᆯᕐΣሜືٙԈ༆dᒱ್ʥπίε
̙ઞীʘஈdШ࿁̴ٙଉɝӺ
,
ᒔ݊
ܘ
Ϟྼყจ່
ձഗɛ˸䖭೯ٙf
IL-1
ၾҵᝨस
дඤձ
༺ڌ
ѩʊϓ̌fኽ
2010
ϋ
ܓ
Ң̈
و
ٙе
ޥ
߅ࣣ
༱ה
dజ༸ٙͣʧ९ʊϞ
IL-1
Ց
IL-33
d
ɧɤɧ၇fͣʧ९၇ᗳ
ܘ
ε˲̌ঐମfତසఱɓԬ
ˢ༰ࠠ
ࠅ
ٙd
א
อ೯ତٙd
א
࿁ᑗґᗫ
༰ڷ
ʲٙͣ
ʧ९dᔊʧνɨf
IL-2
I L - 2
dɦ၈
މ
T
ߤ
͛
ڗ
Ϊɿ
( T c e l l g r o w t h
factor,TCGF)
d͟
CD4 Th1
ପ͛d
CD8 T
ߤ
ɰପ͛
ˇඎ
IL-2
f݊ˏৎ
T
ߤ
ᄣಟٙ˴
ࠅ
ٙe௰ࠠ
ࠅ
ٙ
ߤ
Ϊɿf
IL-2
ஷཀၾ
T
ڌߤ
ࠦٙ
IL-2
աٙतମഐ
ўϾ
ڮ
Դ
T
ݺߤ
ʷdԨආɝʱً࿒fϤ̮d
IL-2
ᒔ̙Րዧ
NK
ߤ
ٙ͛
ڗ
ձᄣ੶Չ૨ෆ̌ঐdԨዧ೯
B
ߤ
͛
ڗ
ձҤٙପ͛f
IL-12
IL-12
Ъٙ͜ཪ
ߤ
˴
ࠅ
݊
T
ߤ
ձ
NK
ߤ
f݊ஹટ
˂್е
ޥ
ձᐏе
ޥ
ٙɓ
ࡈ
ࠠ
ࠅ
ॲ੭fঐϞࣖή
৷ዚٙ
ߤ
е
ޥ
̌ঐf͛
ي
ኪ̌ঐܼ̍ᄣ੶
NK
ߤ
ձ
T
ߤ
ٙ૨ෆঐɢf
IL-18
IL-18
f݊
ڐ
ϋԸอ೯ତٙ
ߤ
Ϊɿdഐၾ
ߤ
lz
ڦ
ᔷኬஷ༩ၾ
IL-1
Чďঐၾ
IL-12
ЧdՈҤ໕
ᆯeҤช
ݑ
ٙ͛
ݺي
f
IL-4
d
IL-5
ၾཀઽˀᏐ
IL-4
݊͟
Th2
ߤ
ପ͛fՉ͛ଣ̌ঐ݊ሜື
IgE
ձ٭ɽ
אߤ
ෘა
ߤ
ʧኬٙе
ޥ
Ꮠഈf݊٭ɽ
ߤ
ٙ
͛
ڗ
Ϊɿϊၾ
IL-3
ΝЪ͜dՐዧ٭ɽ
ߤ
ᄣಟf
IL-5
͟
Th2
ߤ
ձዧ
ݺ
ٙ٭ɽ
ߤ
ପ͛f˴
ࠅ
̌ঐ݊
Րዧෘა
ߤ
͛
ڗ
ձʱʷdዧ
ݺ
ϓᆞෘა
ߤ
d
ᄣ੶Չ૨ෆ͛ᔥٙঐɢfίᙀᔥช
ݑ
ࣛձཀઽˀ
Ꮠशषࣛٙෘაᄣε˴
ࠅ
݊͟
IL-5
ˏৎٙf
IL-5
ձ
IL-4
ٙ̌ঐʝ̂d
ڮ
ආ
Th2
ߤ
ʧኬٙཀ
ઽˀᏐfձ
IL-2
e
IL-4
Νdᄣ੶ϓᆞ
B
ߤ
Υϓ
Ig
d
तй݊
IgA
f
ཀઽˀᏐఱ݊
Th2
ݺߤ
ཀ৷d˸Їˏৎе
ޥ
̻ፅ
̰ሜf
ط
ᐕཀઽ੬ٙ͜ಯઽᐕ
ج
d̙Դ
Th2
࿁ཀઽࡡ
ପ͛
ߗ
աdಯˇ
IL-4
ٙପ͛f
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