保健 - 第86期 - page 63

61
ၝΥజኬ
“餓死”癌細胞新說
NF-
κ
B
是控制能量轉換的“掌門人”
NF-
ǂ
B (nuclear factor kappa B,)
уࣨᔷ፽Ϊᅰf̴݊
Sen
ձ
Baltimore
ί
1986
ϋd࠯΋੽
B
૸ˋ୚
ߤ
ٙ୚
ߤ
ࣨ౤՟
ي
ʕᏨ
಻Ցٙɓ၇ࣨஐͣΪᅰf
NF-
ǂ
B
πί׵᜗lz΢၇୚
ߤ
ʕd
̴ٙ̌ঐᄿ
ع
f
NF-
ǂ
B
ݺ
ʷ
ܝ
dၾ୚
ߤ
ᄣಟe͛
ڗ
ʷe୚
ߤ
඄ಂe୚
ߤ
࡙ɳe
ف
सձе
ޥ
ˀᏐഃٙ΢၇͛նତ
൥ࢹࢹ޴ᗫfᒔၾ໕ᆯٙ೯͛e೯࢝ձऍᆗeᔷ୅Ϟ੗ʲᗫ
ڷ
f̴݊୚
ߤ
ᇞ୐᜗છՓঐඎᔷ౬ٙ¨౛
ژ
ɛ©f
(
Ԉ̛ྡ
)
能量是癌細胞生存的“命根子”
ࠅߤ
ቦঐඎʑঐ͛πfঐඎٙପ͛݊͟А૰༶፩Զഗ୚
ߤ
໧ൃጟձःंЪ
މ
ࡡࣘd୚
ߤ
ቦഹጟ჏༆ٙЪ
͜dਗ਼ᙲɝٙൃ໧ጟʱ༆ϓ˯●აdίᇞ୐᜗̌ঐ͍੬ձःԶഗ̂ʱٙઋ
ر
ɨd˯●აึආɝᇞ୐᜗lzආ
Бɧ┖აృᐑၾःʷᐟაʷˀᏐdίృᐑʕӊʱɿ໧ൃጟ̙ପ͛
36
ɧᐟა໗㹷
(ATP)
d
٫ܝ
Զഗ୚
ߤ
͛π
ٙঐඎfձ͍੬୚
ߤ
ɓᅵdঐඎɰ݊ᐖ୚
ߤ
͛πٙ¨ն࣬ɿ ©d̴ɰ݊ቦʱ༆໧ൃጟԸ՟੻ঐඎdШ͟׵ᐖ
ߤ
ٙ͛
ڗ
Ҟ஺d໧ൃጟўඎֻֻʔԑdவࣛdᐖ୚
ߤ
ఱ̀ც዆ΥঐඎԶഗٙዚՓd˸౤ԶՉҞ஺͛
ڗ
ʘ
ה
ცfᐖ୚
ߤ
ҷᜊঐඎԶഗٙዚՓ݊ε˙ࠦٙ
,
ԷνdᐖਿΪٙମ੬઼ਗd̙ঐఱ݊Չʕٙɓ
ٙዚ
Փf˸૸ˋᆯ
މ
ԷdՉ੬Ԉٙ
myc
ਿΪٙମ੬઼ਗdঐኬ
ߧ
Ԫა୭૫㺛
A
Υϓମ੬ᄣ৷dԴᐖ୚
ߤ
ίॹःً
࿒ɨdঐପ͛ɽඎ
ATP
˸တԑІԒঐඎცӋdԴᐖ୚
ߤ
ᄣಟf
抑制
NF-
κ
B
功能可使癌細胞“餓死”
ཀ̘ɰϞ޼Ӻ
ڌ
׼d
NF-
ǂ
B
ίᐖसٙ೯͛ʕ೯౨ഹЪ͜
,
ШՈ᜗ٙዚଣʔ૶ูfϾ
ߵ
਷޼Ӻɛࡰவϣ
೯ۍ
ତd
NF-
ǂ
B
છՓഹவԬᐖ୚
ߤ
ঐඎԶᏐ˙όٙᔷ౬dν
؈
ҵՓə
NF-
ǂ
B
ٙ̌ঐdᐖ୚
ߤ
ఱʔঐܲ๫ც
౬ঐඎٙ˙όdഐ
؈
ఱึԴආɝঐඎԶᏐʔԑًٙ࿒d
ޟ
Ї¨ቯϥ©fཀ̘ɰಀҪɓԬҤА၍ᄣ͛ٙʷᐕ╙
ي
މ
̙˸ॎᕸᐖ୚
ߤ
մఖٙА၍d࿚ᓙ࿁ᐖ୚
ߤ
ٙᐄቮԶᏐdԴᐖ୚
ߤ
ϥɳҖ࢙
މ
¨ቯϥ©ᐖ୚
ߤ
ዚՓၾவϣٙอ೯ତʔΝf࣬ኽவ
೯ࡈ
ତdϞૐ̙రҬՑһϞࣖٙᐖस
ط
ᐕ˙όfவϣอ೯ତᒔϞɓ
йʘஈdఱ݊ν
؈
NF-
ǂ
B
ၾɓ၇ጟ҇षᖹ
ي
ɚ͠ᕐᯝ΍ΝЪ͜
ۆ
ቯϥᐖ୚
ߤ
ٙࣖଟึɽɽ౤৷f
NF-
κ
B
抑制劑有待進一步開發
͟׵ҵՓ
NF-
ǂ
B
̌ঐd̙Դᐖ୚
ߤ
¨ቯϥ©வ
อ೯ତd䥊೯əɛ
࿁ආɓӉක೯
ط
ᐖอᖹٙ
ܠ
Ͻf͟׵ᎇഹ
NF-
ǂ
B
ڦ
໮ᔷኬ௄ࢰٙ˚ू׼ࣦʷd০࿁׌ήҵՓᔷ፽ٙ΢
ᐑືdϓ
މ
शष
ط
ᐕձᖹ
ي
ක೯ٙɓ
ࠠᓃf
ཀ̘ɰಀϞཀʔˇ
NF-
ǂ
B
ҵՓኒٙ޼Ӻfʕᖹ˙ࠦ͵Ϟ
ה
ઞীfԷνdϞ޼Ӻᗇ׼dᜳ
ٺ
ٙɧ㺳ᗳʷΥ
ي
ʘᜳ
ٺ
A
ձ
F
d̙˸ஷཀҵՓ
NF-
ǂ
B
ձ
AP-1
d੽ϾҵՓԪ໗ᐖ୚
ߤ
ٙ͛
ڗ
fɦν
,
Ϟజѓ၈dͩ࿹໢ʕٙ
ڀ
აeᑞර९eၠ঩९ഃѩ̙ஷཀҵՓ
NF-
ǂ
B
ৎՑҵᐖٙЪ͜f
ኽజ༸dତʊ΍Ϟ
700
ε၇
NF-
ǂ
B
ҵՓኒ஗೯ତ
א
ΥϓdШ݊
ܘۍ
ˇ͜׵ᑗґf޶ԸdνОतମ׌
ҵՓ
NF-
ǂ
B
ٙ
ݺ
׌dಯˇҵՓኒٙʔԄˀᏐdʥ݊ɓ
ڣࡈ
ც༆Ӕٙᗭᕚfอ޼Ӻٙഐ
؈
dೌဲ݊
ഗ༆Ӕவ
ᗭᕚ੭ԸəɓᇞᏣΈfᏎԑ
൮ޜ
f
ᇜ፨΋͛jઆλfቡజٝ༸ί
2011
ϋ
8
˜dϞ
ߵ
਷܎਷ଣʈኪ৫ഃዚ࿴ٙ޼Ӻɛ
ࡰdл͜໑ᐖ୚
ߤ
Ъ޼Ӻd೯ତν
؈
ҵՓəɓ၇̣ਂ
NF-
ǂ
B
ٙ
ي
,
ఱঐ¨ቯϥ©
ᐖ୚
ߤ
ٙอ˙
ج
dϞпʦ
ܝ
࿁ᐖसٙ
ط
ᐕdԨʊਗ਼޼Ӻഐ
؈
ߐІ್{୚
͛
ي
ኪ‘ᕏႦɪ೯
ڌ
fऊࢹෂԸd˿ɛࣈኧlᗫ׵¨ቯϥ©ᐖ୚
ߤ
ɓႭdཀ̘ɰଫϞ
ה
ၲdШʔٝၾɪ
อ೯ତϞОਜйkᒔϞdజ༸ʕ౤ʿٙ˜
NF-
ǂ
B
™݊
ޟ
ჿk˜̴
ঐછՓഹঐඎᔷ౬™ɦ݊
ޟ
ჿɓΫԫkঐщഗɓԬᔊ׼ҫ
ٙ༆ᙑdᜫ
ݔ
ԬϞϤც
ٙᛘ٫ᄣ
ڗ
ɓԬ੬ᗆfɤʱชᑽf
ᛘ٫
௓˙
2012
ϋ
1
˜
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