61
ၝΥజኬ
“餓死”癌細胞新說
NF-
κ
B
是控制能量轉換的“掌門人”
NF-
ǂ
B (nuclear factor kappa B,)
уࣨᔷΪᅰf̴݊
Sen
ձ
Baltimore
ί
1986
ϋd
B
ˋ
ߤ
ٙ
ߤ
ࣨ՟
ي
ʕᏨ
Ցٙɓ၇ࣨஐͣΪᅰf
NF-
ǂ
B
πίlz၇
ߤ
ʕd
̴ٙ̌ঐᄿ
ع
f
NF-
ǂ
B
ݺ
ʷ
ܝ
dၾ
ߤ
ᄣಟe͛
ڗ
eʱ
ʷe
ߤ
ಂe
ߤ
࡙ɳe
ف
सձе
ޥ
ˀᏐഃٙ၇͛նତ
ࢹࢹᗫfᒔၾ໕ᆯٙ೯͛e೯࢝ձऍᆗeᔷϞʲᗫ
ڷ
f̴݊
ߤ
ᇞછՓঐඎᔷ౬ٙ¨
ژ
ɛ©f
(
Ԉ̛ྡ
)
能量是癌細胞生存的“命根子”
ࠅߤ
ቦঐඎʑঐ͛πfঐඎٙପ͛݊͟А૰༶፩Զഗ
ߤ
ൃጟձःंЪ
މ
ࡡࣘd
ߤ
ቦഹጟ༆ٙЪ
͜dਗ਼ᙲɝٙൃጟʱ༆ϓ˯●აdίᇞ̌ঐ͍੬ձःԶഗ̂ʱٙઋ
ر
ɨd˯●აึආɝᇞlzආ
Бɧ┖აృᐑၾःʷᐟაʷˀᏐdίృᐑʕӊʱɿൃጟ̙ପ͛
36
ࡈ
ɧᐟა໗㹷
(ATP)
d
٫ܝ
Զഗ
ߤ
͛π
ٙঐඎfձ͍੬
ߤ
ɓᅵdঐඎɰ݊ᐖ
ߤ
͛πٙ¨ն࣬ɿ ©d̴ɰ݊ቦʱ༆ൃጟԸ՟ঐඎdШ͟ᐖ
ߤ
ٙ͛
ڗ
Ҟdൃጟўඎֻֻʔԑdவࣛdᐖ
ߤ
ఱ̀ცΥঐඎԶഗٙዚՓd˸ԶՉҞ͛
ڗ
ʘ
ה
ცfᐖ
ߤ
ҷᜊঐඎԶഗٙዚՓ݊ε˙ࠦٙ
,
ԷνdᐖਿΪٙମ੬઼ਗd̙ঐఱ݊Չʕٙɓ
ࡈ
ࠠ
ࠅ
ٙዚ
Փf˸ˋᆯ
މ
ԷdՉ੬Ԉٙ
myc
ਿΪٙମ੬઼ਗdঐኬ
ߧ
Ԫა୭૫㺛
A
Υϓମ੬ᄣ৷dԴᐖ
ߤ
ίॹःً
࿒ɨdঐପ͛ɽඎ
ATP
˸တԑІԒঐඎცӋdԴᐖ
ߤ
ᄣಟf
抑制
NF-
κ
B
功能可使癌細胞“餓死”
ཀ̘ɰϞӺ
ڌ
d
NF-
ǂ
B
ίᐖसٙ೯͛ʕ೯౨ഹЪ͜
,
ШՈٙዚଣʔูfϾ
ߵ
Ӻɛࡰவϣ
೯ۍ
ତd
NF-
ǂ
B
છՓഹவԬᐖ
ߤ
ঐඎԶᏐ˙όٙᔷ౬dν
؈
ҵՓə
NF-
ǂ
B
ٙ̌ঐdᐖ
ߤ
ఱʔঐܲც
ࠅ
ᔷ
౬ঐඎٙ˙όdഐ
؈
ఱึԴආɝঐඎԶᏐʔԑًٙ࿒d
ޟ
Ї¨ቯϥ©fཀ̘ɰಀҪɓԬҤА၍ᄣ͛ٙʷᐕ╙
ي
dΪ
މ
̙˸ॎᕸᐖ
ߤ
մఖٙА၍d࿚ᓙ࿁ᐖ
ߤ
ٙᐄቮԶᏐdԴᐖ
ߤ
ϥɳҖ࢙
މ
¨ቯϥ©ᐖ
ߤ
fՉ
ዚՓၾவϣٙอ೯ତʔΝf࣬ኽவ
೯ࡈ
ତdϞૐ̙రҬՑһϞࣖٙᐖस
ط
ᐕ˙όfவϣอ೯ତᒔϞɓ
ࡈ
त
йʘஈdఱ݊ν
؈
ਗ਼
NF-
ǂ
B
ၾɓ၇ጟ҇षᖹ
ي
ɚ͠ᕐᯝΝЪ͜
ۆ
ቯϥᐖ
ߤ
ٙࣖଟึɽɽ৷f
NF-
κ
B
抑制劑有待進一步開發
͟ҵՓ
NF-
ǂ
B
̌ঐd̙Դᐖ
ߤ
¨ቯϥ©வ
ࡈ
อ೯ତd䥊೯əɛ
ࡁ
࿁ආɓӉක೯
ط
ᐖอᖹٙ
ܠ
Ͻf͟ᎇഹ
NF-
ǂ
B
ڦ
ᔷኬࢰٙ˚ूࣦʷd০࿁ήҵՓᔷٙ
ࡈ
ᐑືdϓ
މ
शष
ط
ᐕձᖹ
ي
ක೯ٙɓ
ࡈ
ࠠᓃf
ཀ̘ɰಀϞཀʔˇ
NF-
ǂ
B
ҵՓኒٙӺfʕᖹ˙ࠦ͵Ϟ
ה
ઞীfԷνdϞӺᗇdᜳ
ٺ
ٙɧ㺳ᗳʷΥ
ي
ʘᜳ
ٺ
ა
A
ձ
F
d̙˸ஷཀҵՓ
NF-
ǂ
B
ձ
AP-1
dϾҵՓԪ໗ᐖ
ߤ
ٙ͛
ڗ
fɦν
,
Ϟజѓ၈dͩʕٙ
ᕔ
ڀ
აeᑞර९eၠ९ഃѩ̙ஷཀҵՓ
NF-
ǂ
B
ৎՑҵᐖٙЪ͜f
ኽజ༸dତʊϞ
700
ε၇
NF-
ǂ
B
ҵՓኒ೯ତ
א
ΥϓdШ݊
ܘۍ
ˇ͜ᑗґfԸdνОतମ
ҵՓ
NF-
ǂ
B
ٙ
ݺ
dಯˇҵՓኒٙʔԄˀᏐdʥ݊ɓ
ڣࡈ
ც༆ӔٙᗭᕚfอӺٙഐ
؈
dೌဲ݊
ഗ༆Ӕவ
ࡈ
ᗭᕚ੭ԸəɓᇞᏣΈfᏎԑ
൮ޜ
f
ᇜ፨͛jઆλfቡజٝ༸ί
2011
ϋ
8
˜dϞ
ߵ
ଣʈኪ৫ഃዚٙӺɛ
ࡰdл͜໑ᐖ
ߤ
ЪӺd೯ତν
؈
ҵՓəɓ၇̣ਂ
NF-
ǂ
B
ٙ
ي
ሯ
,
ఱঐ¨ቯϥ©
ᐖ
ߤ
ٙอ˙
ج
dϞпʦ
ܝ
࿁ᐖसٙ
ط
ᐕdԨʊਗ਼Ӻഐ
؈
ίІ್{
{ߤ
͛
ي
ኪᕏႦɪ೯
ڌ
fऊࢹෂԸd˿ɛࣈኧlᗫ¨ቯϥ©ᐖ
ߤ
ɓႭdཀ̘ɰଫϞ
ה
ၲdШʔٝၾɪ
ࠑ
อ೯ତϞОਜйkᒔϞdజ༸ʕʿٙ
NF-
ǂ
B
݊
ޟ
ჿk̴
ঐછՓഹঐඎᔷ౬ɦ݊
ޟ
ჿɓΫԫkঐщഗɓԬᔊҫ
ࠅ
ٙ༆ᙑdᜫ
ݔ
ԬϞϤც
ࠅ
ٙᛘ٫ᄣ
ڗ
ɓԬ੬ᗆfɤʱชᑽf
ᛘ٫
˙
2012
ϋ
1
˜
讀者信箱
ᔊқᖍ
બ˴ܵ
Kan Ch i Hon