保健 - 第79期 - page 38
36
ਖ਼ᕚઞ॰
е
ߗޥ
աၾІԒе
ޥ
ष
ІԒе
ޥ
षٙ೯षዚՓ
ϬӸЛ
ދ
ञ
ؿ
ೕञዀԹcʋ̰ѧͲѹc͌
ک
ႏ
ݯ
c
˿ॶၤɎ߸ዀԹτᗐe
ȹdɁɣʗୂᓱୀ
ߋ
Ε߄
ߊ
ࣂ౨౦ΕॳຽၤЛ
ދ
ୀ
༤ޚߋ
cԒЛ
ދ
ୀ
ߋ
ผೕ́
ࡀ
əϤ
cᘗᙩΦ
ؿݠ
Л
ދ
ୀ
ߋ
cɺྦྷϬӸୂᓱೕ̳́
Л
ދ
Ꮆ೮c͛ЩྦྷϬӸҊ
ࡈ
ଐ́ȿЛ
ދ
Շeԯ
ʭᅕ̰
ؿ
ୀ
ߋ
cԯ˲ॶɖՇԷқԹֶ
ٲ
ଊ
ݯ
ಲॶ
ر
ྸeЎိ
ر
ྸ˿ܺိΐॖֺው
ݠ
cϊࣂ
ڏ
ҝϤྦྷϬӸୂᓱೕ̳́Л
ދ
Ꮆ೮cЩ
ϬӸЛ
ދ
ʦᎶeိʦᎶԚዀଐ́ञଉҝᛰ
ΰˮଊᐽѷट
ر
ࣂcగီ
ݯ
ϬӸЛ
ދ
झञ
(Autoimmune disease,AID)
e
ɀdଊ
ك
Ɂʑ߲ஐЛ
ދ
˲ॶ
ؿ
T
ୀ
ߋ
˿˞ʗ
ݯ
ႤХֲ
T
ୀ
ߋ
(Th)
ሁຝֲ
T
ୀ
ߋ
(Treg)
c
ک
ّԗԯଐ́
ୀ
ߋ
ΐɥ́
ذ
˲ॶ
ؿ
ɺɌʗ
ݯ
ԭ
ێ
i
Th1
Th2
e
Th1
ୀ
ߋ
ʗ؊
IL-2
IFN
ƺ೩c˲ॶ
ݯ
ߋ
ʑञ෬́
ذ
ʍኒୀ
ߋ
Л
ދ
h
Th2
ୀ
ߋ
ʗ؊
IL-4
d
IL-5
IL-13
೩c˲ॶ
ݯ
ୀ
ߋ
̔ञ
ࡈ
෬
́
ذ
ΰၤᛰྸʦᎶe
IFN-
ƺ
IL-4
ޚ
ʃ
ܜ
Ҋc
ሁઁ㠥
Th1
Th2
ୀ
ؿߋ
ᒷᄈ˲ॶeԚԯ
ܛړ
̡
ጫcΣȹ̭̖˾̡ጫc˥Ή
Th1
ʿΉඪધϤ
ߎמ
Ϭ
ӸЛ
ދ
ֲझञe
ɍd
2005
αc
ޢ
Ӡณೕଊȹᗘɺ
כ
Th1/Th2
ؿ
ୀ
ߋ
ԓ
ະc˞ʗ؊
IL-7
ݯ
˚c՜Ί
ݯ
Th17
eϊୀ
ߋ
ະ
Λ
༠ٲ
IL-17A
d
IL-17F
d
IL6
TNF2
Ƹ೩cϤɺ
ଐ́
IFN2
ƺ
IL24
eଊτ
ޢ
Ӡ
עٲ
c༦൴
ؿ
Th17
ୀ
ߋ
ΦΕcผʵೕᗲ
ؿࠇ
ϬӸЛ
ދ
ֲझञcΣΛ
ೕֲೝʝटe
ІԒе
ޥ
षٝεˇ
τం༞ီc͌
ک
ೕଊ
ؿ
ɁᗘϬӸЛ
ދ
ञτ
40
ိc
˿ʗ
ࡈݯ
ೕֲᙩೕֲԭᗘc
ک
ّၤፘඨʘ
ޚ
ᗐc
ݯ
ୄֲ́झञh܃ّၤᖞ
ذ
d̔ඬdܷτᗐeད
܃ȹঁӪΡe
ࡈ
ೕֲ
AID
Ɍτኂւऋଔֲ
AID
Σ
ࠇ
ट
ϪಲɈdኽ̯ˊ͆
ر
ຽ
೩ا
ڈ
ኂւऋଔֲ
AID
Σ
ᗘ
ࠓ
Ꮶֲᗐຝ
ا
dӡֲౚऌᆖɾʗeଊ˞ᗘ
ࠓ
Ꮶ
ֲᗐຝ
ݯ
ԝc
ޜޜ
ਥ
כ
Л
ދ
Շ
ؿ
ɻ˅cᗐຝеଊ
ؿ
ᛰʝ
ٲ
ଊe
ᗳࠬ᐀ᗫື
ف
̯ञܰЛ
ދ
ӡྦྷᗐຝୂᓱcА
ݯ
ଔɯୂᓱଐ́Л
ދ
ʦᎶc
ܨ
ञɁ϶ɻτϬӸҊˮଊcီ
ݯ
ᗘ
ࠓ
Ꮶ
ΐɥ
(Rheumatoid factor, RF)
cܰ̚ȹိৌྦྷ
IgG-Fc
ː
ؿݒ
Ҋeᗐຝᚤʑไɻτ
RF-IgG
ᇲ
ذ
cไᇐτ
Л
ދ
ୀ
ߋ
ا
टୀ
ߋ
ࣴᅼcไɻ˚߬
ؿ
ୀ
ߋ
ΐɥτ
IL-1
d
IL-8
d
TNF-
Ƹ
IFN-
ƺeԒୀ
ߋ
ΐɥԚไᇐ
ୀ
ݠߋ
ʝcଐ́ᇒ
ࡈ
ˋ㢓cτवᕝசড়Ϫີ
ؿ
А
͂eᗲ
ࠇ
ࣂ˿
ߎ
ञɁ
ݠ
৽шᗒc˞ϭٜѷɺeԯ
܃cᑹผୃʥΛኂւc
ޅ
ϭʥ́՜e
е
ߗޥ
աၾ࿔ɔۨӿ
ف
Ⱥ
ێ
ञ
ݓ
ֲӥ
ا
ᓯီȺӥcܰȹိͅȺ
ێ
ӥ
ا
ञ
ݓ
(HBV)
ʵ
ؿ
झञe
HBV
ܷɁԎ൬Ƀӥୀ
ߋ
c
ʑЛ
ދ
ӡ
ؿ
§ᖫП¨cԎೕ৽ҞᎾcϊࣂగผι
ܷȿ
HBV
ӥୀ
ؿߋ
ฌඬcʵ
ا
टe
ا
ट
ߗ
ɺԷ
ሬࣂ
ؿ
Թ˅c
HBV
ɺԷྵ֛
ؿ
c
ا
टЩᔝɃྺ
ֲ༦ೡeɣΛᅕྺֲ
HBV
ᙙّၤྺֲȺ
ێ
ӥ
੩ا
ّΦΕЛ
ދ
ՇcЩԯЛ
ދ
ʱୀ
ߋ
ྦྷ
HBV
ʥԯҊ
ࡈ
е߲Л
ދ
Ꮆ೮ֶ̳Л
ދ
Ꮆ೮ГɎeι
ݯ
Ⱥ
ێ
ӥ
ا
ᗒ
؝
ؿ
भ̳
ࡈ
ΐeֺ˞cਿࡼ
ࠨ
ႏ
ݯ
c̨वЛ
ދ
Շc
ۺ
͓ϬӸ˚৽Л
ދ
cɷॶኝȺӥe
ྺֲȺӥ̔cȹԒྺֲඨܷञc
౨ٽ
ᗒ˞؝ᓞ
ࡈؿ
ΐc˿ॶɖܰၤೕ́ȿЛ
ދ
Շτᗐe
е
ߗޥ
աၾ໕ᆯ
ɁɍɣЛ
ދ
˲ॶɾȹcగܰЛ
ދ
ဟ഼˲ॶcτȿ
ိ˲ॶcʑȹ̭ˮଊଔୀ
ߋ
cผ͓Щc
Ϥԉ˅ȿົᆔ
ؿ
ѼιeົᆔञɁగܰͅ
כ
ଐ́ȿЛ
ދ
Շc
כ
ܰྦྷົᆔҊ
ࡈ
еଊ߲Л
ދ
Ꮆ೮ֺ
ߎ
e
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