保健 - 第88期 - page 56

54
΢၇
אيݭ
ي
ٙʕ
ݭ
f͵̙Ԉ׵׳࢛ᇞٙ๫࢛e
୚ഽ
९ݭ
ிϓٙ୚
ߤ
ฦෆfᒔϞఱ݊ିᶶ९ഃᇞ୐
᜗խі㺛ॹ˶ˏ
ߧ
͛
ي
ःʷཀ೻ٙღᖟf
缺氧與疾病
࿔׌ॹःၾशषٙᗫ
ڷ
d˚ूաՑɛ
ٙࠠൖd
ޟ
ЇϞɛႩ
މ
d¨ॹः݊ɓʲ࿔׌षٙ࣬๕f©ᑘɭ
ᐖसeϼϋ׌ᖝьഃٙ೯͛
೯א
࢝ேၾॹःҰɪᗫ
ڷ
d
੻ᗫ
ء
ձઞ॰f
ॹःၾᐖसᓒ౳
2012
ϋ
5
˜
3
˚
ߕ
਷ӊ˚߅ኪၣ१జ༸d࣬ኽР
ط
ԭ
ɽኪٙ௰อ޼Ӻϓ
၈؈
d୚
ߤ
ॹः̙ঐ݊
ݔ
Ԭᐖस
Ҟ஺ᓒ౳ٙ˴
࣬๕f޼ӺίɖᗳᐖसjԪ໗ᐖe
ഥᐖeӿᐖe٬ᐖeф੫ᐖeঈ໗ᐖձ
ߞ
ᐖʕdѩ
೯ତᐖ୚
ߤ
lzٙўःඎɨࠥfԨႩ
މ
d຅ўःඎࠥ
Ց฽Э೻
ܓ
ࣛdක֐
ڗ
̈อА၍d੽Ͼ౤৷୚
ߤ
ٙ
ўःdᅲࣛಯᇠəᐖसٙ೯࢝dШՉ
ܝ
Ϊᐖ୚
ߤ
ᄣɽdһ̋ॹःٙઋ
ر
̈ତdҖϓəె׌ృᐑdᐖ
ߤ
༹੻˸ᓒ౳f
ၽᝄኪ٫͵൛׼d຅ᐖ୚
൳ڗ൳ߤ
ɽd
ఱึ̈ତॹःdᐖ୚
މߤ
əᐏ՟ः
ंdఱึᔷ୅ՑՉ̴͍੬ٙኜ֜
̘fԨ࠯
ܓ
ҬՑᐖ୚
ߤ
ᔷ୅ٙ
ݑ
Ѝሯᅺা
HDAC3
ʿ
WDR5
ᒔ೯ତdᐖ୚
ߤ
ॹःࣛd̙
Ⴐ೯
HIF-l
ƹਿΪd੽Ͼ
ݺ
ʷᔷ
୅ਿΪ
TWIST
ձ
Snail
dԴᐖ୚
ߤ
੻˸ᔷ୅f
ॹःၾϼϋᖝьस
ڛ
ဧভऎᎰष
(AD
dϼϋᖝьस
)
ٙ೯
षዚՓЇʦ͊׼dϞ΢၇ʔΝኪႭfΪϤd
Їʦ֠ॹ˶Ϟࣖٙ
ط
ᐕ˓
ݬ
fШί೯षཀ೻ʕd̙
˸޶̈ၾ࿔׌ॹःً࿒੗ʲ޴ᗫf
1.
ॹःၾƺዠ४ᅵ㹻
(
ƺ
-Amyloidpeptide
d
A
ƺ
)
ٙ͛
ϓϞᗫf
A
ƺႰኬ
ݺ
׌ःᗳ
ي
ሯٙପ͛dˏ
ߧ
ग़຾
ʩ࡙ɳd
ڮ
AD
ٙषଣᜊʷf
2.
͟׵ग़຾ʩ༰Չ̴ଡ଼ᔌ୚
ߤ
dஈ׵һ৷ٙ
ݺ
׌ः
л͜dഐΥःίА૰lzɰ̀඲ᔷᜊ
މ
༷ᕎः
ܝ
ʑঐ
ᘝ౳Ցଡ଼ᔌʕd஗୚
הߤ
л͜f
缺氧的發生
੽ɪ
¨ःආɝ୚
ߤ
ٙ
ݴ
˥ᇞ©̙˸޶̈d຅̮
ޢ
ः஗іɝ٬
ظ
eᘝ౳ɝА૰dΎၾА
ߎ
ஐͣഐΥd
͟А૰ృᐑ፩৔ՑΌԒd௰
ܝ
஗ଡ଼ᔌ୚
ߤ
ᙲ՟л
͜fவ̬
ᐑືdᐑᐑ޴ϔdၡ੗޴ஹd̈ʔ੻̒
ᓃࢨ፹dщ
ۆ
Չʕ΂ɓᐑື̈ତॎၛࣛdே
ึԴ୚
ߤ
੻ʔՑ̂ԑٙःd
א
ʔঐ̂ʱл͜ःd
ϤࣛԒ᜗ఱ
೯ࠅ
͛ɓӻΐٙषଣᜊʷd၈
މ
ॹः
(hypoxia)
fॹः೯͛ٙࡡΪϞɨ̬ࠦ၇j
іɝ٬
ظ
ٙःʔԑ
іɝ٬
ظ
ٙःʔԑeᘝ౳ɝА૰ٙ஺
ܓ
ಯ࿔eᘝ౳
ඎಯˇd੬Ԉஈ׵৷ࡡe৷٤
א
ஷࠬʔԄஈfɦ
א
ίխі༸द॥
ڜא
෦e঍௅
٬א
௅शषࣛfԒ᜗
މ
ə࿁ॹःٙ˾Ꮅd̙̈ତխі̋ଉ̋Ҟdஷंඎᄣ
̋fͤᇮࣛԈ
ڡ
ഓf߰˾Ꮅʔԑd̙ˏৎ
ܢ
׌٬˥
໕dᘌࠠࣛึ̈ତխіҵՓf
А
ߎ
ஐͣҷᜊ
А
ߎ
ஐͣᅰඎʔԑ
א
׌ሯҷᜊd
੬Ԉ׵΢၇மА
א
ɓःʷ၁ʕ
ݭ
fமАࣛА
ߎ
ஐͣᙳःཀ
ˇfɓःʷ၁ʕ
ݭ
ࣛdः஗
ɓःʷ၁ᘩ
ن
׌՟˾ၾА
ߎ
ஐͣഐΥfःΣଡ଼ᔌᘝ౳ٙ
ܓ
ಯ࿔fமАࣛषɛͤᇮ
ႏͣfɓःʷ၁ʕ
ݭ
dͤᇮя
ᙶࣹ
ߎ
Ѝf
Аృᐑღᖟ
ΌԒ׌А૰ృᐑღᖟdଡ଼ᔌА
ݴ
ඎಯˇf
੬Ԉ׵ːɢস။ʿ;дഃࣛf;дઃ٫ː፩̈ඎಯ
ˇʿΌԒॹःᘌࠠdଢ଼ʿ΢ࠠ
ኜ֜f҅௅׌ృᐑ
ღᖟdԈ׵এ၍
ف
eਗএഎᅵ೷ʷeАࣼҖϓʿࣼ
෦dːЄʿ໘૚෦੬Κʿ͛նf
ߤ
л͜ःମ੬
ଡ଼ᔌ୚
ߤ
л͜ःମ੬dԈ׵↾ʷ
ي
eିʷ૫eᐟഃ
預防勝於治療
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