保健 - 第96期 - page 55
ਖ਼ᕚઞ॰
55
வ၇ࢨମ၈
މ
ఊࣨ㹷აε࿒
(single nucleotide
polymorphism)
dᔊ၈
މ
SNP
f
SNP
dί
30
ᄂ
ࡈ
ਿʕdӊ
100
Ց
300
ࡈ
ਿఱึ
Ϟɓ
ࡈ
̈ତf
SNP
݊ɛ࿁
ݔ
ԬशषՈϞชٙࡡΪfШϞəவ
ࡈ
ࡡΪdԨʔ˾
ڌ
ఱɓ֛ึઃ
၇ݔ
शषdШν
؈
Ύ
̋ɪϞՉ̴ᐑྤΚᎈΪ९dԟఱٙᆽ݊ึᄣ̋ઃ
ݔ
၇शषٙࠬᎈfኽజኬdͦ
ۃ
ঐл͜
SNP
ආБࠬᎈ
ᅰኽ፲ෂ༊ٙशष
ܘ
εdՉʕܼ̍jήʕऎமАe
ᚙً
ߤ
மАe٭
ߛ
सe
2
ۨጟ҇षe
ڛ
ဧভऎᎰसe
ߎ
थᆱeၚग़ʱसʿε၇ᐖसഃf
SNP
ၾ٬ᐖ
ʕኪ٫၈
(2013)
dԙʦ
މ
˟d௰ɽᅼٙᗫ
SNPs
ၾशषٙᗫ
ڷ
ٙӺ݊
2007
ϋజѓٙ
WTCCC
ධͦd༈ධͦ࿁
14000
Τઃ٫ձ
300
Τ͍੬ɛЪə
ӺfԷνՉʕ೯ତdՈϞɪͤ͛
ڗ
ΪɿաਿΪ
ٙ
ݔ
Ԭ
SNPs
ٙɛ໊d೯͛
ڢ
ʃ
ߤ
ۨ٬ᐖٙዚଟ৷
͍੬ɛ໊f
SNP
ၾ٭
ߛ
स
ዦɽлԭኪ٫
(2013)
ίɓධ௰อٙӺʕ೯ତd٭
ߛ
ਿΪ
FTO
ٙ
SNP
ᜊʷd࿁Ԓ
BMI
ٙᜊʷପ͛
ᜑഹٙᅂᚤf
BMI
݊ɓ၇੬ٙ͜ඎ٭
ߛ
ٙᅺd
̴ඎɓ
ࡈ
ɛٙࠠdԨ࣬ኽԒ৷ආБ͍ࣧf˼ί
ʱؓəਗ਼
ڐ
17
ຬɛٙᅰኽ
ܝ
d൛ྼ
FTO
ਿΪҏΐ೯
͛
SNP
ٙɛd˼ٙࠠһࠠd˼
ࡁ
ٙ
BMI
ᜊʷ
ࠅ
ˢ
ʔᙳ੬
SNP
ٙɛ৷̈
7%
f
SNP
ၾၚग़ʱस
ʕኪ٫
(2014)
࿁ੂۨၚग़ʱसᓙਿΪ
1
(DISC1)SNPs
ආБəӺd࿁ྼ᜕ଡ଼
100
Էၾ࿁ଡ଼
100
Էٙ
DISC1
ʕ
2
ࡈ
̌ঐఊࣨ㹷აε࿒ЗᓃԴ
͜ਿΪʱۨ
ڃ
˪ආБʱۨӺdഐ
೯؈
ତdՇଡ଼ၚ
ग़ܸᅰ࿁ˢՈϞᜑഹࢨମfྼ᜕ᗇdੂۨၚग़
ʱसձ
DISC1
ਿΪε࿒ʘගπίʲᗫ
ڷ
dΝ
ࣛɰ݊ชਿΪʘɓf
基因維護
保障健康
ਿΪ࿁
ڭ
ღɛٙੰʘࠠ
ࠅ
,
வ݊ʔԊϾఏٙd
ШவԨʔഃႭᐑྤΪ९ఱʔࠠ
ࠅ
dщ
ۆ
ఱึ྅ɪ
ૢఊᗡЪ
މ
ᅼؐdܲਿৣ࿁ࡡ
ۆ
dΥϓՑɓ
ૢ
RNA
d
٫ܝ
ཀʲe
ࡌ
ུdҖϓ
ڦ
ࢹ
RNA
(mRNA)
f͟
DNA
Ց
mRNA
வ
ࡈ
ཀ၈
މ
ᔷ
f
ᔕᙇࣛd
mRNA
ਗ਼
DNA
Ցٙ፲ෂ
ڦ
ࢹdܸኬஐͣ
ሯٙΥϓfί
mRNA
ٙҏΐɪdϞ
3
ࡈ
ஹᚃٙਿd
މ၈
ɧᑌᇁɿdӊ
ࡈ
ɧᑌᇁɿึ࿁Ꮠɓ
ࡈ
ऄ
ਿაfϾΥϓɓ֛ٙஐͣሯf͟
mRNA
Ցஐͣሯ
வ
ࡈ
ཀ၈
މ
ᔕᙇf
人類基因組計劃
މ
ə
ࠅ
ዌ༆ɛᗳ
ה
ϞਿΪٙЗໄձ̌ঐdԨॎᙇՉ
Ό፲ෂ
ڦ
ࢹd
1985
ϋ
ߕ
߅ኪ̈əɛ
ᗳਿΪଡ଼
ࠇ
ྌd
1990
ϋdவ
ࠇࡈ
ྌ͍ό઼ਗf
ࠇ
ྌ࿁ɛᗳ
23
࿁
ݑ
ЍٙΌ
DNA
ආБҏdԨ
ᖭՓᗫٙ፲ෂྡᗅe
ي
ଣྡᗅձҏΐྡᗅf
2001
ϋ
2
˜dʮбəɛᗳਿΪҏΐྡᗅf
2003
ϋ
,
ࠇ
ྌ
නлҁϓf
Ӻ೯ତdɛᗳਿΪଡ଼ʕ
ה
ўਿΪٙᅰͦ
މߒ
2-2.5
ຬ
ࡈ
fϾɛᗳٙ͛ϼषϥ
ה
Ϟ፲ෂ
ڦ
ࢹఱίՉʕfၾ
ɛᗳशषϞᗫٙ
ڦ
ࢹɰʔԷ̮fኽ၈dఱίୋɓ
ݑ
ЍɪఱϞ
3141
ࡈ
ਿΪdவԬਿΪʕπίٙॹ
ၾ
350
၇शषϞᗫfՉʕܼ̍ᐖसe֮
ږ
ಌषഃf
基因變異是人對疾病有易感性的原因
ɛᗳਿΪଡ଼ʕᜑͪd
ה
Ϟɛٙ
DNA
ҏΐ
99.9%
݊
Νٙd̥Ϟ
0.1%
ʔΝd౬Ԋʘd
30
ᄂ
ࡈ
ਿ࿁
Ϟ
300
ຬ
ࡈ
πίഹܳᄳٙࢨମfவԬࢨମ݊͟ఊ
ࡈ
Зᓃٙਿٙҷᜊdуɓ၇ਿ̤ɓ၇ਿ
ה
՟˾f՟˾ٙ˙όϞՇ၇dуᔷ౬ၾᗵ౬f
ᔷ౬
(traansition)
ܸ݊Νᗳਿʘගٙ՟˾dν໗☫
ᤲ
(A)
☫џ
(G)
՟˾i
ߤ
☩Ṝ
(C)
໗☩Ṝ
(T)
՟ה
˾f
ᗵ౬
(tranvertion)
ܸ݊ʔΝᗳਿʘගٙ՟˾dν໗
☫ᤲ
(A)
໗☩Ṝ
(T)
ߤא
☩Ṝ
(C)
՟ה
˾i☫
џ
(G)
ߤ
☩Ṝ
(C)
א
໗☩Ṝ
(T)
՟˾i
ߤ
☩Ṝ
(C)
☫ᤲ
(G)
໗א
☫
ޛ
(A)
՟˾i໗☩Ṝ
(T)
໗
☫ᤲ
(A)
א
☫џ
(G)
՟˾f
1...,45,46,47,48,49,50,51,52,53,54
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