專題探索
預防勝於治療
55
受體與健康
ա
ৣ
ڦ
Դ
ɛ݊͟၇
הߤ
ଡ଼ϓdʔΝ
ߤ
ٙБ
މ
ც
ࠅ
ሜɓ
ߧ
dʑঐԴዚቇᏐlz̮ᐑྤᕏٙᜊʷd˸
Ӌ͛πձ೯࢝dவఱϞ፠
ߤ
ගٙʝஷ
ڦ
ࢹd
ʲʹ
ݴ
f
ߤ
ෂ
ڦ
ࢹٙ˙ό̙ஷཀቌ
ߤ
ٜ
ટટᙃeஷཀ
ߤ
ගe
א
ஷཀ
ߤ
lzూᕏٙ
ڦ
ࢹෂ
ӻ୕Ըෂ
ڦ
ࢹfவ
ࡈ
ӻ୕݊͟
ڦ
ࢹ
ي
ሯeաe
ߤ
lz
ڦ
Դɧʱଡ଼ϓfա
(receptor)
ٙʷኪ͉ሯ
݊ጟஐͣeইஐͣ
א
ᒙইஐͣഃf݊ɓᗳʧኬ
ߤ
ڦ
ᔷኬٙ̌ঐஐͣሯdঐᗆйմఖᐑྤʕ
၇ݔ
ฆ
ඎʷኪ
ي
ሯу
ڦ
ࢹ
ي
ሯ dԨ̙ၾʘഐΥdᒔ
ঐஷཀʕʧٙ
ڦ
ࢹ׳ɽӻ୕dᙃ೯
ܝ
ᚃٙ͛ଣˀ
ᏐfவԬঐၾաतମഐΥٙʷኪ
ي
ሯ၈
މ
ৣ
(ligand)
dɰ̣
ڦ
Դ
(messenger)
dνዧ९e
͛
ڗ
Ϊɿeग़ሯeᖹ
ي
e
يݭ
eΈձբഃd၈
މ
ୋɓ
ڦ
Դ fϾί
ߤ
lzෂ
ڦ
ࢹٙʃʱɿʷΥ
މ၈ۆي
ୋɚ
ڦ
Դdν
Ca2+ cAMP
e
cGMP
ഃf
G
ஐͣਅᑌաၾ
ڦ
ᔷኬ
աʱ
މ
ߤ
lzաձᇫաՇ၇fᇫաܼ̍
ᐑًաe
G
ஐͣਅᑌաeऄაஐͣዧ㺛աf
G
ஐͣਅᑌա
(GPCR)
ɦ၈ɖ
༨ࡈ
ᇫƹᑮૅա
Ԉ̛ྡf
G
ஐͣ݊ɓᗳձ
GTP
א
GDP
ഐΥdЗ
ߤ
ᇫ
ߤ
ᆉ
̮ࠦٙմஐͣd͟ƹeƺeƻɧ
ࡈ
ԭਿଡ଼ϓfϞՇ၇
ۨj
у
ݺڢ
ʷۨ
(
ƹeƺeƻɧၳഐΥ
GDP)
ձ
ݺ
ʷۨ
(
ƹ
ԭਿഐΥ
GTP
dၾƺeƻԭਿʱᕎ
)
f
G
ஐͣਅᑌաٙ
ڦ
ࢹᔷኬཀ̙ᓥॶ
މ
jৣν
ዧ९
➔
աdաᜊd
G
ஐͣ
ݺ
ʷ
➔
Ъ͜ɓԬ
㺛ν໗㹷აᐑʷ㺛
AC
dуաٙࣖᏐஐͣf
➔
͛
ϓୋɚ
ڦ
Դν
cAMP
➔
ዧ
ݺ
Ꮠٙஐͣዧ㺛Դೌ
ݺ
ٙ
PKA
ᜊ
މ
Ϟ
ݺ
ٙ
PKA
➔
ᅂᚤ㺛
א
̌ঐஐͣ
ᐟაʷ
➔
ˏৎᏐٙ͛
ي
ࣖᏐνਿΪ
༺ڌ
e
ي
ሯ˾
ᑽٙሜືe
ݖ৶ߤ
ഐഃf
ߤ
Ϟա ٙπίdҢ
ࡁ
ʑঐԈeᛓՑeၲഹdʑঐชաՑ͛
ݺ
ٙ၇၇ֱ၅fա
݊
ڌߤ
ࠦɓҪᑋٙᕁ dࣛՍชաഹॸᐿልᕏٙ͛ն
ڦ
ࢹdԴҢ
ࡁ
ঐᎇࣛ࿁lz̮
၇ᜊʷЪ̈ϞлˀᏐdᒈΛᒒΉd͛
ݺ
τᖢfІ
1900
ϋd
Ehrlich
̈ա ɓ൚˸Ըdɛ
ࡁ
࿁աٙӺd͊৾ࢹfٜՑғəɔ。ᑔաٙഐdఱᅺႦഹաӺආɝʱɿ͛
ي
ኪӺච
ݬ
f˸
ܝ
ɦᘱϞε၇աषٙ೯ତfա݊
ڦߤ
ࢹᔷኬٙʕːᐑືd̴ၾ
ߤ
࡙ɳeе
ޥ
e໕ᆯeช
ݑ
शषഃٙ೯͛e೯࢝Ϟഹࠠ
ࠅ
ٙᗫ
ڷ
fΪϤdίʔˇशषʕdତί
ே̙˸ஷཀዧ
אݺ
ҵՓաϾ೯౨࿁शषٙ
ط
ᐕЪ͜f̙˸ཫಂdաӺٙଉɝ೯࢝dਗ਼ึ
ഗତ˾ᔼኪ੭Ըһᔮ၂ٙϓ
؈
f
·
ྡc
G
ஐͣਅᑌա
簡志瀚 Kan Chi Hon
