保健 - 第94期 - page 57

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57
ա᜗ၾ୚ߤ࡙ɳ
୚ ߤ ࡙ɳ݊ɓ ࡈ ˴ਗٙ͟ਿΪӔ֛ٙІਗഐҼ͛ն
ٙཀ೻fɦ၈୚ ߤ ೻ҏ׌ϥɳf୚ ߤ ࡙ɳක֐݊ટ
ա࡙ɳ ڦ ໮d࡙ɳሜછʱɿග޴ʝЪ͜d್ ܝ ݊ஐ
ͣ˥༆㺛 ݺ ʷd௰ ܝ ආɝஹᚃˀᏐཀ೻dኬ ߧ ୚ ߤ
࡙ɳf୚ ߤ࡙ɳஷ༩ϞɧૢdՉʕʘɓ݊˜ᇫա᜗ஷ
༩ ™dίϤஷ༩ʕd΢၇̮ ޢΪ९݊୚ ߤ࡙ɳ઼ٙਗ
ኒdତ˸ Fas-FasLމ ԷႭ׼dFas݊ɓ၇୚ ڌߤࠦա
᜗d݊ɓ၇༨ᇫஐͣf࠯΋ Fasৣ᜗(FasL) Ⴐኬա᜗
ପ͛ɧၳЪ͜dɧၳʷٙFasၾ FasLഐΥܝ dԴɧࡈ
Fas ʱɿٙϥɳഐ࿴ਹ޴ၳϓᐨdіˏəߤ ᆉʕ̤ɓ
၇੭Ϟ޴Νϥɳഐ࿴ਹٙஐͣ FADDfFADD݊ϥɳ
ڦ ໮ᔷ፽ʕٙɓ ࡈ ஹഐஐͣd̙ၾೌ ݺ ׌ٙ˜̒আ
ऄაஐͣ㺛 8™ (caspase 8) 㺛ࡡ೯͛ʹᑌdၳΥεࡈ
caspase 8ٙʱɿdcaspase 8ʱɿ༹͟ఊᗡ㺛ࡡᔷϓϞ
ݺ ׌ٙᕐᗡஐͣdආϾˏৎᎇ ܝ ٙॴᑌˀᏐdԴ୚
ߤ ࡙ɳf
ա᜗ၾ໕ᆯ
ె׌໕ᆯٙतᅄ݊৷ᄣಟeЭʱʷeԨՈϞᔷ୅ঐ
ɢf໕ᆯٙ೯͛݊εᐑືٙա᜗ձ ڦ ໮ᔷኬମ੬ ה
ߧ f໕ᆯٙϘಂ˴ ࠅ ݊ሜછ୚ ߤ ͛ ڗ eʱʷձ࡙ɳ
ڦ ໮ᔷኬମ੬fϾૉಂ ۆ ݊છՓ໕ᆯ୚ ߤ ᓂ ڝ ձ༶
ਗ׌ٙਿΪ೯͛ᜊʷdԴ໕ᆯ୚ ߤ ᐏ੻əᔷ୅׌f
ኬ ໕ߧᆯ୚ߤ ཀ ܓ ᄣಟٙ ڦ ໮ᔷኬମ੬d˴ ڌࠅତ
ί ڮ ୚ ߤ ᄣಟٙ ڦ ໮ᔷኬཀ੶dϾҵՓ୚ ߤ ᄣಟٙ
ڦ ໮ᔷኬཀࢮfཀ੶݊͟׵ڮ୚ ߤᄣಟΪɿପ͛ᄣ
ε fε၇໕ᆯѩঐʱ ؤ ΢၇͛ ڗ ΪɿdϾ໕ᆯ୚ߤ
ஷ੬ேՈϞ޴Ꮠ͛ ڗ Ϊɿա᜗dΪϤd໕ᆯ୚ߤ ̙
ஷཀ˜Іʱؤ ™ዚՓdኬߧ ІԒٙᄣಟfڮ ୚ߤ ᄣಟ
Ϊɿա᜗༺ڌᄣεא ମ੬ዧݺf୚ ߤlz ڦ໮ᔷኬஐ
ͣٙҷᜊfίɛᗳ໕ᆯʕ೯͛᎖ଟ௰৷ٙ߉ᜊ݊ʃG
ஐͣRasٙዧ ݺۨ߉ᜊf ڮ ආ୚ߤ ٙᄣಟfҵՓ୚ߤ
ᄣಟٙ ڦ ໮ᔷኬಯࢮ̙͟׵͛ڗ ҵՓΪɿա᜗ٙಯ
ˇeఄ̰˸ʿա᜗ܝ ٙ ڦ ໮ᔷኬஷ༸ମ੬ ߧהfν
TGF-ƺա᜗ٙಯˇfTGF-ƺ࿁ε၇໕ᆯ୚ߤ ՈϞҵ
ՓᄣಟձႰኬ࡙ɳٙЪ͜f̴ၾTGF-ƺա᜗ഐΥܝ d
̙ਗ਼୚ڜߤထ׵G1ಂf
ա᜗ၾዧ९ٙഐΥඎd̙˸ᅂᚤՉ࿁lzʱؤ ዧ९Ա
፠׌໕ᆯطᐕٙࣖ؈fԷν͜შዧ९ܶҤኒط Ԫᐖd
̳͜● ط ᐕɿࢗ᜗ᐖၾഥᐖd͜ጟͤሯዧ९ط ૸ˋ
୚ߤ ͣАषʿ૸ˋᆯഃf
ա᜗ၾڭ਄طᐕ
ա᜗ၾ ڭ ਄ൢᐕᗫڷ ੗ʲdఱ˸ G ஐͣਅᑌա᜗
(GPCR)މԷd͍νɪ˖ࠑהd GPCRίɛ᜗lzᄿ ڌع
༺dԨ೯౨ഹਿᓾ׌͛ଣЪ͜, ਞၾชٝe͛ಟe͛
ڗeၚग़ഃε၇͛նݺ ਗdՉڦ ໮ෂኬஷ༩̰ٙሜd
ৰ̙˸೯͛ա᜗ष̮dᒔၾе ޥe୚ߤ ࡙ɳeช ݑ
׌शषe໕ᆯഃٙ೯͛e೯࢝੗ʲ޴ᗫfΪϤdᖹ
ي̙˸ஷཀዧאݺҵՓGPCRϾ೯౨طᐕٙЪ͜fϞ
జ༸၈d੽ڐ ఻ɤϋᖹ೯ي࢝ٙዝ̦޶dΌଢ 70%ٙ
ᖹي ே݊০࿁GPCRٙfͦۃ ɪ̹ٙᖹي ʕdۃ50၇
௰࿫ቖᖹي ʕٙ20%݊GPCR޴ᗫᖹي dνԪ໗ᐖᖹ
يፕཤᅃ(Zoladex) eҤଡ଼ᔌᶶᖹeၚग़ᗳᖹيෳಢ
̻(Olanzapine)ഃfΌଢᖹ ي̹㰦ɧʱʘɓٙʃʱɿ
ᖹي݊ GPCRٙዧݺኒ אܶҤኒfGPCR͍ˏჯഹΌଢ
อᖹيٙ޼೯ԫุf
Biological Receptors & Health
Receptors are vital for health: defective receptor protein for removing LDL (low-density lipoprotein: “bad cholesterol”) causes familial
hypercholesterolemia (LDL soars at young age); blocked acetylcholine receptors (neuromuscular junction): myasthenia gravis (muscle
weakness). Toll-like receptors (TLRs) vital for innate immunity are expressed in “sentinel cells” (macrophages and dendritic cells)
enhancing immunity. Pathologic organisms depend on adhesin to combine with specific receptors in our cells: a target to abort
infections. Fas receptor binds with Fas ligand (FasL) to form a signaling complex with FADD / caspase-8 for apoptosis (programmed
cell death). For cancers, the TGF-beta receptor is commonly involved for growth arrest and apoptosis. Receptors also enable hormones,
e.g., reduction of hormone receptors to control breast cancers. As G protein coupled receptors (GPCRs) sense molecules outside cells
and activate inside signals for cellular responses, they are closely related to immunity, apoptosis, infections, tumors, etc.: mechanism
of 70% of (20% of top-selling) drugs, e.g., Zoladex hormone for breast cancer; antihistamines (anti-allergy), olanzapine for psychiatry,
etc., the potential is tremendous!