保健 - 第108期 - page 56

56
ԭၚᶶ
(spermidine)
f
ԭၚᶶ࠯ϣ݊ίၚ૰ʕ೯ତ
ٙdԨΪϤϾ஗նΤfԭၚᶶɰπί׵ɓԬ࠮
ي
ν
ϓᆞԪ཈
(Hard cheese
d
ٺ
ɻ
)
eጋ⊵eԌᗳձΌಠ
ي
ഃʕfෳήл޼Ӻɛࡰజѓ
(2016)
jਗ਼ԭၚᶶ̋ɝ˥
ʕᒸཱϓᆞٙϼཽd೯ତԭၚᶶ̙˸Ⴐኬϼཽٙː
Є୚
ߤ
ІአЪ͜dԴʘરৰːЄʕɓԬ̰̘̌ঐձ
ೌ̀
πίٙ௅ʱdᄣ੶əːЄٙ̌ঐdАᏀࠥЭd
ආϾ
ݺ
੻һ
ڗ
ɮf
༶ਗf
ߕ
਷ɓ
޼Ӻʃଡ଼d
މ
ə᜕൛༶ਗνО౤৷
ɛ᜗ٙІአЪٙ͜ዚՓd޼Ӻɛࡰਗ਼ɓଡ଼ʃཽਂਿ
ΪҷிdᜫՉ᜗lzٙІአ᜗೯̈ፃΈၠЍdᝈ࿀೯
ତʃཽί຾ཀə̒ʃࣛٙൺӉዚ༶ਗ
ܝ
dՉЄЂʕ
ٙІአ᜗ᄣ̋dԨ˲ঐܵᚃᄣٜ̋ЇൺՑ
80
ʱᙒf
ط·
ᐕᐖसj
ٺ
f
̨ᝄٙ޼Ӻ൛ྼ
(2015)
dԸІʃᥗɿᜳ
ٺ
ٙе
ޥ
ሜືஐͣ
GMI
d̙˸ί᜗lzձ᜗઼̮ਗ٬ᐖ୚
ߤ
І
አዚՓdᜫᐖ୚
ߤ
˜ІҢəᓙ™ϾҵՓ໕ᆯٙ͛
ڗ
f
Ԩ̙౤৷නཔٙᐕࣖdԴ٬ᐖ୚
ߤ
Іአၾ࡙ɳ˜Շ᎘
ደ™f
௥̆Ӵ㹷
B
f
௥̆Ӵ㹷
B
݊ʕᖹ௥̆
ה
ўϓʱfྼ
᜕ഐ
ڌ؈
׼d௥̆Ӵ㹷
B
̙Ⴐኬɛࢗ᎕ᐖ
HeLa
ߤ
ІአdԨˏৎІአᅺႦ׌ஐͣ
Bec l i n -1
༺ڌ
ᄣ̋ʿ
LC3
ŗᔷᜊ
މ
LC3
ŘiІአҵՓኒ
3-MA
ʔШ̙˸ҵՓ
༈ІአЪ͜dϾ˲఻˷ҁΌ৕ᔷՉҤᄣಟЪ͜d౤
ͪՉ͛
ڗ
ҵՓЪ͜
މ
ІአԱ፠׌ٙf
߮ਞ᜽f
߮ਞ᜽݊੽ʕᖹ߮ਞʕ౤՟ٙ͛
ي
᜽fྼ
᜕൛׼d߮ਞ᜽̙Ⴐኬ
ߞ
SGC-7901
ߤ
Іአf
ط·
ږݡ
Ⴥसj
ནᖸf
ʕᖹནᖸ̙ҷഛ
ږݡ
ჅसषઋfΪནᖸʕў
Ϟɓ၇˜ମནᖸ᜽™ٙ
ي
ሯd̙ίग़຾୚
ߤ
ႰኬІአ
Ъ͜d̋Ҟ૶ৰ
ږݡ
Ⴥसጐၳٙ
ߧ
ष׌ମ੬ஐͣf
Ϥ̮dঐႰኬ୚
ߤ
ІአٙʕᖹᒔϞjරҊ㹷eᖿ╵
ᜳe۴ර९e
ڡ
ႃ९eͣ᎘ॽӴ㹷ഃf
µ
ҵՓ୚
ߤ
ІአЪ͜
ط
ᐕशष
ط·
ᐕᐖसj
࿺Ѐ૶ၷf
݊ʕᖹ࿺Ѐ౤՟
ي
fঐஷཀɨሜ
mTOR
ڦ
໮ஷ༩dҵՓɛ٬໗ᐖ୚
ߤ
ӻ
A549
ߤ
ᄣಟdԨ
Ⴐኬ
A549
೯͛ІአfШᑌΥԴ͜࿺ЀձІአҵՓኒ
3-MA
̙ঐһϞࣖ೯౨࿺ЀҤ໕ᆯᄣಟЪ͜f
Ϥ̮dঐҵՓ୚
ߤ
ІአٙʕᖹᒔϞj୚Ԕe͞ɖeʇ
ᣡ㹼ഃf
۲ྐྵf
̻੬͜׵
ط
ᐕဳशٙ۲䄑d݊ɓ၇୚
ߤ
Іአ
ٙҵՓኒfਗ਼۲䄑ձ੬ٙ͜ʷᐕձᅺཪᖹ
ي
ഐΥৎ
ԸdҵՓᐖ୚
ߤ
Іአঐɢd࿁
ط
ᐕɓԬϞ
ߗ
ᖹ׌ٙ
ᐖसd
ڋ
Ӊ޶ԸϞɓ֛ࣖ
؈
f
ط·
ᐕᜤⶶ
ಭਟ
ڡ
ብ९
(Wortmannin)
f
݊ɓ၇ІአҵՓኒfঐ
तମ׌ҵՓ
P13k
dʍᓔ
ڜא
ᓙІአ᜗ٙҖϓfᜤ㹲
೯Ъኬ
ߧ
ٙ˜ऎ৵™ฦෆࣛdπίІአዧ
ݺ
ତ൥dಭ
ڡ
ብ९ঐஷཀҵՓІአ
ݺ
׌dಯჀᜤ㹲೯Ъ
ߧה
ٙऎ৵ฦෆfՈϞ
ڭ
ᚐग़຾ٙЪ͜f
Autophagy & Health
Akin to housekeeping, autophagy increases with aging. Tumors are initially inhibited but eventually survives; nasty cancer cells use it
to promote adaptation, eg, chemotherapy resistance. In Parkinson’s, glucocerebrosidase (GBA) gene mutation leads to
α
-synuclein
accumulation; in Alzheimer's,
β
-amyloid peptide accumulates. Though killed by autophagy, the tubercle bacilli (TB) can also exploit
autophagy for protection; though the hepatitis B virus is killed by autophagy, the Zika virus may activate abnormal autophagy
affecting fetal neuro development. Promotion of autophagy: (1) Polyphenols in coffee: sustained autophagy in mice liver, heart and
muscles (2) Spermidine (from hard cheese, mushrooms, beans and whole cereals): autophagy in mice heart muscles: with “tidying
up”, strengthening, blood pressure lowering and longevity (3) Physical exercises: sustained autophagy (4) Lingzhi: autophagy (mice
and petri dish) in lung cancer cells: suicidal effect; cisplatin chemotherapy also enhanced (5) Maidong extracts: autophagy in human
cervical cancer cells (6) Bitter ginseng extracts: stomach cancer cell autophagy (7) Cat’s claw (uncaria) improves Parkinson’s disease
symptoms. Inhibition of autophagy: (a) Huaier extracts on human lung adenocarcinoma cells (b) Quinine: combo with chemotherapy
or targeted therapy (c) Wortmannin: neuroprotective in post-convulsion brain damage.
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