專題探索
43
ਗএഎᅵʷ
ίਗএഎᅵʷٙषଣฦʕdА၍̻Є
ߤ
ٙ
ᄣಟৎ䋠ࣨːٙЪ͜fϾஐͣዧ㺛
C
ίᄣಟˀᏐʕৎ
ഹࠠ
ࠅ
ٙ
ڦ
ᔷኬЪ͜fஐͣዧ㺛
C
ٙ৷
༺ڌ
ঐҵՓ
Cycline D
e
Cycline E
˥̻dϾ
P27
ஐͣ˥̻
ۍ
ᜑഹ৷
͍੬
ߤ
dආɓӉӺ൛ྼ
P27
ஐ˛݊Ӕ֛А၍̻
Є
ߤ
ঐщආɝ
ߤ
ಂආϾᄣಟٙᗫᒟf
ᗳࠬ᐀ᗫື
ف
ᗳࠬ᐀ᗫື
ف
݊ɓ၇˸ᇫᛖ႟ᄴ
ߤ
ᄣ͛eА၍
ᑇҖϓeఊࣨ
ߤ
ऍᆗdආϾழ৶
႙ڧ
ձᗫືॎᕸ
މ
तᅄٙ࿔
ف
सशषfϞӺ
ڌ
dᗳࠬ᐀ᗫ
ື
ف
ᇫϓᜄၪ
ߤ
ί
ߤ
ಂʕମ੬
ݺ
ᚔdя໕
ᆯᅵᄣ͛d݊ிϓ㡣৶ॎᕸٙɓ
ࡈ
ࠠ
ࠅ
ࡡΪfઃ٫
ٙᇫଡ଼ᔌʔ
༺ڌ
P21
e
P16
ձ
P15
f̮༊᜕೯ᴒd
̍ў
P16
ٙ໗ष
༱ݭ
̙ҵՓᗳࠬ᐀ᗫືᗫᇫϓ
ᜄၪ
ߤ
͛
ڗ
fਗ਼༈ष
༱ݭ
ء
ɝРኒᗫື
ف
ਗ
ي
ٙաଢ଼ᗫືdঐϞࣖҵՓՉᗫື
ف
सًf
細胞增殖缺陷
ၾ
ߤ
ᄣಟॹϞᗫٙशषܼ̍ጟ҇षഥषeग़
ৗБशष
ڛ
ဧভऎᎰषձ֮
ږ
ಌषձΎ͛ღᖟ
மАഃf
ጟ҇षഥष
ጟ҇षഥष݊ጟ҇षٙ࿔ഥᛔԨ೯सf˴
ࠅ
݊͟
ഥʃଢʷኬ
ߧ
ഥ̌ঐಯৗfίጟ҇षྼ᜕ᅼۨ
ʕdᒱೌ
G1/S
ಂ
Cycline
ʿ
CDK2
e
CDK4
ٙҷᜊdШ
݊Ӻ೯ତഥʃଢ
P27kip1
༺ڌ
ᄣ৷dνл͜
p27kip1
ˀ່ྺࣨ㹷აஈଣ̙
ڮ
ආ৷ጟᐑྤʕӻᇫ
ߤ
ٙᄣ
ಟf݂ϞႩ
މ
dጟ҇षഥष݊͟
P27kip1
ཀ
༺ڌ
ձ
pRb
Эᐟაʷً࿒ΝЪ͜dҵՓഥʃ၍ɪͤ
ߤ
e
ӻᇫ
אߤ
А၍lzͤ
ߤ
ٙᄣಟ
ߧה
f
調控細胞週期與疾病防治
ஷཀሜછ
ߤ
ಂ˸৷ɓԬशषٙԣ
ط
˥̻Ϟ䋠
ᄿ㢥ٙ
౻ۃ
fఱ˸໕ᆯ
މ
ԷdӺ໕ᆯ
ߤ
ᄣಟ
ಂٙतᓃʿிϓ̰છٙዚՓ
໕މ
ᆯٙषΪኪeषଣ
ኪʿൢᓙe
ط
ᐕఢ֛əʱɿ͛
ي
ኪٙਿᓾfΝࣛd
ɰ
މ
ઞ॰Ҥᐖᖹ
ي
ٙЪ͜ዚଣe
މ
อҤᐖᖹ
ي
ٙண
ࠇ
ʿᑗґΥଣ͜ᖹԶə̙ቦԱኽfՉʕ̙䋠j
1.
抑制
Cycline
或（和）
CDK
的表達和活性
̮lz
ྼ᜕ᗇྼdΣ໕ᆯ
ءߤ
࢛Ҥ
Cycline D1
Ҥ
א
ˀ
່ྺࣨ㹷ა̙ίɓ֛
ܓ
ɪҵՓ٬ᐖ
ߤ
͟
G1
ಂ
Σ
S
ಂཀನdԨᔷᔷʷ
ߤ
ٙҖ࿒i
CDK
ҵՓኒ
Flavopiridol
݊ɓ၇ᄿᗅٙ
CDK
ҵՓኒdίॶᅙဧ
ዢ
ܓ
˥̻̙ҵՓ
CD1
e
CD2
e
CD4
ձ
CD6
dϾԴ
ߤ
৾ထ
G1/S
ಂձ
G2/M
ಂf
2.
提高
CDI
的表達和活性
CKI
ਿΪ݊໕ᆯҵՓਿ
Ϊdί໕ᆯʕ
CKI
ਿΪձஐͣϞʔΝ
ܓ
ٙମ੬d
ਗ਼͛ۨ
CKI
ν
P16INK1a
e
P21Kip1
e
P27Kip1
e
ਿΪኬɝɛ໕ᆯ
ߤ
̙Դ
ڜߤ
ထ
G0/G1
fν
ਗ਼̮๕
P27
ᔷ
ݑ
ɛҖᆯ
ߤ
eԪ໗ᐖձᄀۚᐖ
ߤ
dঐҵՓՉ͛
ڗ
dᔷె
ڌ
ۨdಯˇ
ڢ
࠴
ߤ
dΝࣛԴ
G2/M
ߤ
ᄣεiνਗ਼
p21cDNA
ᔷɛً͠໗e໘e٬ձٜ໑ᐖഃε၇ᐖ
ߤ
d
̙ҵՓՉ͛
ڗ
ձᄣ੶Չ࿁ʷᐕٙઽชf
Cell Proliferation & Health
Catering for our aging, trauma, prompt initiation of immune response and natural cell death (life span of red blood cells is 102 days; in
6-7 years, all our cells are replaced once), our cells proliferate well. Cyclins are regulatory proteins active at specific phases in the cell
life cycle coded in order: G0, G1, S, G2 and M. CDKs are cyclin dependent kinases (enzymes) but, against them are the CDK inhibitors
(CDIs), e.g., P21, P27, etc. New anti-cancer drugs aim at specific cell cycle phases, e.g., to inhibit cyclin and/or CDK expressions or
activities; laboratory + animal studies confirm injection of antibodies against cyclin D1 or “antisense oligonucleotides” suppresses
the cell cycle at the G1/S phase. The CDK inhibitor Flavopiridol has a broad-spectrum of activity against various CDKs even at low
concentrations: applicable clinically. As CDI genes are suppressive genes for malignancies, enhancing the expression or the activity of
CDIs suppresses malignancies, e.g., by introducing “wild type” CDI genes into malignant cells stops the cell cycle at the G0/G1 phase.
Transfection of P27 to human astrocytoma, breast and nasopharyngeal cancer cells inhibits their growth. P21 transcribed to human
thyroid, brain, lung and rectal cancers also inhibits their growth. The future is bright!
