保健 - 第105期 - page 42

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CDK6ٙཀ༺ڌ πίձ̈ତCDI༺ڌʔԑձ߉ᜊdԷ
ν༰εԈՑInk4̰ٙݺ e Kipўඎٙಯˇfவேԑ˸
࿴ϓ໕ᆯ୚ߤ ٙ೯͛ձ೯࢝f
ڐ ϋ޼Ӻ೯ତdӿᐖٙ೯͛ၾ୚ߤ ඄ಂሜછɰϞɓ
֛ᗫ ڷfɔӿष ݭᙳ੭٫੬Ϟɔӿष ݭ HBV዆Υɝ
Cycline AਿΪʕ৷༺ڌ f༺ڌ̈ٙలΥஐͣॹ˶࿁
Cycline Aٙॎᕸdʔঐࠥ༆
Ͼܵᚃ೯౨Ъ͜f˜ ژذ ɽ
ක§dԴ୚ߤ඄ಂҞ஺ආɝʱ
൓ಂdኬ ߧ ୚ ߤ ೌືՓήᄣ
ಟϾߧ ᐖf
Ϥ̮d޼Ӻᒔ೯ତdίɛᗳ
Ԫ໗ᐖձ໘໕ᆯઃ٫ʕdϞ
ࣛ̈ତ CDKʱɿձCyc l i ne
A e B e De E ഃٙਿΪٙ ڌ
༺ɪʺdνઃ٫ٙCycline D
ٙ ༺ڌჃ৷׵͍੬٫f
Ўಿष
Ϟ޼ӺႩ މ dЎಿषࣛึ̰̘еޥ ̌ঐ݊͟׵ช ݑ
Ўಿषݭ HIV ࣛd̙ԴT ୚ߤ CDK1ɪٙ཈ऄაಞਿ
ཀʱᐟაʷϾ̰ݺdԨԴCycline BጐၳfCdk1݊୚
ߤආɝM ಂٙ˴ࠅ ዧ㺛dCycline Bٙጐၳۆ݊ආɝM
ಂٙ̀ࠅ ૢ΁fΪϤdHIVชݑ ึிϓ୚ߤ඄ಂ৾व
ίG2ಂϾʔঐආɝ Mಂd௰୞ኬߧ T୚ ߤ࡙ɳd̰̘
еޥ ̌ঐf
সϼ
সϼɰМᎇ୚ ߤ ᄣಟٙतᅄᜊʷfνᎇ䋠ϋᙧٙᄣ
ڗ d୚ ߤ ඄ಂ ܓڗ ׼ᜑַڗ f୚ ߤ ʱ൓஺ ܓ ᜑഹᜊ
࿔fՉࡡΪ˴ࠅ ݊G1ಂ׼ᜑַڗfίসϼٙ୚ߤ ʕd
Cdk2eG2-ycline(CyclineA eB) ഃٙ༺ڌࠥЭfᒔϞ
Ⴉ މdসϼձ୚ ߤCDIཀ ༺ڌϞᗫf
ഥʃ၍ගሯ׌षᜊ
ഥʃ၍ɪͤ୚ ߤ ึաՑε၇Ϊ९ٙฦෆdˏৎʃ၍
ගሯ୚ ߤ ٙᄣಟe ࡌ ూձᕸϥdΝࣛМϞɓӻΐ୚
ߤ ඄ಂሜછஐͣٙɪሜfഥॹАฦෆܝ dՉ̮᜖௅
˜ᄣಟ୚ߤࣨҤࡡ(PCNA) §ݑЍජ׌୚ߤ Ԙ஺ᄣεd
ԨМϞCyclineD1eD3e BeAўඎʿCDK4e CDK2
ஐͣўඎʿ ݺ׌ٙᄣ̋f
୚ߤ ඄ಂஐͣԱ፠׌ዧ㺛ҵՓΪɿ(CDI) f
ՉʕdCDK݊୚ߤ ඄ಂሜືٙʕːᐑືdCycline݊
CDK͍ٙሜືΪɿdCDI ݊CDK ٙҵՓΪɿdஷཀ
ၾCDKڢ ΍ᄆഐΥϾҵՓCDKݺ ׌ٙd݊ၾcycline-
CDK Ъ͜޴࿁Ҥٙࠠࠅ ዚՓʘɓf
࡬Ԫਗ ي ୚ ߤ ٙ CDI˴ ࠅ ̍
ܼ Ink4( ܼ̍P16 e P15e P18
ʿ P19)eKip(ܼ̍p21e p27e
p57) ʿ GADD45ഃf
ה ˸Ϟɛਗ਼Ϥɧ٫ˢఏႭd
˜ CDKʱɿ̙˸ൖމ˜ˏᏗ™d
Cycline̙ൖމ˜ ژذ™dCDI
̙ൖ މ˜ ۀԓ™f୚ߤ ඄ಂٙ
༶Ъdɧ٫ॹɓʔ̙f
細胞週期調控異常與疾病
୚ ߤ ඄ಂሜછମ੬̙ኬߧ ୚
ߤ ᄣಟཀאܓ୚ ߤᄣಟॹ௘d
Շ٫ேึኬ ߧ ɓԬशषٙ೯͛f˸ɨ࿜፽ɓԬᗫ׵
शषၾ୚ߤ ඄ಂᗫڷ ٙజ༸f
細胞增殖過度
ၾ୚ߤ ᄣಟཀ ܓ Ϟᗫٙशषܼ̍໕ᆯeЎಿषeস
ϼeഥʃ၍ගሯ׌शषeਗএഎᅵ೷ʷeᗳࠬ᐀ ޒ
ᗫືف eӿeഥᜄၪʷe ۃ ΐ໗٭ɽeࡡ೯׌Аʃ
ؐᄣεसe࢕ૄ׌ߎ ୚ߤ ᄣεसeვ࢜षഃf
໕ᆯ
໕ᆯ୚ߤٙᄣಟ඄ಂၾ͍੬୚ ߤ޴Чfேܼ̍G1ಂe
Sಂe G2ಂձ MಂfՉʕ SeG2 e Mಂ༰೵d඄ಂٙ
ڗ ೵ɰᎇ G1ಂϾମfཀ̘Ⴉ໕މ ᆯ୚ ߤᄣಟ༰Ҟ݊
͟׵Չ୚ ߤ ඄ಂ༰೵dତί೯ତഒɽεᅰɛ᜗໕ᆯ
ٙ୚ߤ ඄ಂʔසʔˢΝᗳଡ଼͍ٙ੬୚ ߤ ඄ಂ೵dϾ
݊޴Ν ڗ༰אd΍ʕࡡΪɰ݊G1 ಂᜊ ڗfν͍੬࠮
၍ɪͤٙ୚ߤ ඄ಂމ 144ʃࣛd࠮၍ᐖމ 250.8ʃࣛf
ߞ ɪͤމ66 ʃࣛdߞ ᐖމۆ80.0 ʃࣛf
ͦ ۃ Ⴉމ d໕ᆯٙ೯͛ၾCyclinsٙཀඎ༺ڌe CDK
ٙᄣεeCDI ༺ڌʔԑձ߉ᜊϞᗫf
Ϊ މ ޼Ӻ೯ତdԪ໗ᐖeߞ ᐖe࠮༸ᐖϞ Cy c l i n e
D1 ٙཀ༺ڌܓ fί໕ᆯ୚ ߤ ʕᒔ̙˸ԈՑCDK4 ձ
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