保健 - 第105期 - page 41
專題探索
41
細胞增殖與健康
細胞增殖的意義
ߤ
ᄣಟ
(cell proliferation)
݊͛
ي
ᐿ
ࠃ
ɿ˾ٙ˙ό
ʘɓf݊͛
ي
͛
೯ڗ
ԃٙࠠ
ࠅ
ਿᓾf
ߤ
ஷཀᄣ
ಟԸ̂͛ն
ݺ
ਗཀʕসϼeฦෆձϥɳٙ
ߤ
d
˸ၪ͍ܵ੬ٙ͛ଣ
ݺ
ਗձ̌ঐfԷνd৶ிА
ڭߤ
ܵ䋠ସٙʱ
ݺ
ਗd˸ʔᓙ̂ྪն̥Ϟ
120
˂ٙ
ߎ
ߤ
fɛ
ߤ
ɽ
ߒ
6-7
ϋఱҁΌһ͛ɓϣd
ν
؈
வԬ͍੬ٙ
ࡌ
ూዚՓա
ڜ
dνաՑ׳࢛ฦෆd
ɛఱึί˂lzϥɳfᒔϞdϞࣖٙе
ޥ
ˀᏐ઼ٙ
ਗdɰ̀ஷཀ
ߤ
ᄣಟԸྼତf
細胞增殖通過細胞週期實現
ߤ
ᄣಟ݊ஷཀ
ߤ
ಂԸྼତٙf
ɓ
ࡈ
ߤ
ಂуɓϣ
ߤ
ʱfܸ݊
ߤ
ɓϣʱ
ഐҼՑɨɓϣʱəٙཀ
א
ගཞࣛගf̙ʱ
މ
̬
ࡈ
ච
ݬ
jу
G1
ಂe
S
ಂe
G2
ಂձ
M
ಂf
G1
ಂd݊
DNA
ልႡٙ௪ಂi
S
ಂd݊
DNA
ٙልႡಂdልႡɰ
ఱ݊Υϓอٙ
DNA
fΥϓٙ
ߵ
˖݊
synthesis
d
ה
˸՟
̴ٙୋɓ
ࡈ
ο͎
S
dу၈
މ
S
ಂi
G2
ಂd݊ʱٙ
௪ࣛಂi
M
ಂdɰఱ݊
ߤ
ʱಂdܼ̍
ߤ
ࣨٙʱ
ձ
ߤ
ሯٙʱf
ߤ
ʱٙ
ߵ
˖݊
mitosis
d՟̴
ٙୋɓ
ࡈ
ο͎
M
dఱ၈
M
ಂf
G1
ಂձ
G2
ಂ݊πί
M
ಂՑ
S
ಂe
S
ಂՑ
M
ಂʘගdගཞ
gap
ٙୋɓο͎݊
G
d
މ
əਜʱdఱʱй՟Τ
މ
G1
ಂձ
G2
ಂf
細胞增殖狀態下的三類細胞
ᄣಟٙԉ
ܓ
Ըd
ߤ
̙ʱ
މ
ɧᗳj
1.
ᄣಟ
ߤ
၈א
ಂ
ߤ
dஹᚃʱٙ
ߤ
ܲ
ߤ
ಂΌ༶ᔷfν৶
ߤ
ഃf
ߤ
ᄣಟܸ݊
ߤ
ᅰඎٙᄣ̋f݊ၪܵ
ࡈ
ߤ
ᅰඎձ̌ঐ࿁̻ፅٙਿᓾf̴ձ
ߤ
ٙʱ
ʷe࡙ɳΝ
ڭ
൛əlz
ߤ
ٙᅰඎձሯඎٙ࿁ፅ֛f
ߤ
ᄣಟ݊ஷཀ
ߤ
ಂྼତٙf
աՑၚሜືձછՓfɧЗ߅ኪ
ߕ
ٙ
Leland H. Harwell
e
R. Timothy Hunt
ձ
ߵ
ٙ
Sir.Paul
M.Nurse
͟ί౧ͪ
ߤ
ಂʱɿሜછዚՓ˙ࠦЪ̈߉্̈ᘠϾᐏ
2001
ϋፕԎဧ͛ଣʿᔼ
ኪᆤfӺ൛
ߤ
ᄣಟν
೯؈
͛८d̈ତཀ
אܓ
ʔԑd̙ঐኬ
ߧ
ᘌࠠ
؈ܝ
dνᐖᜊe
ෂशषeৗБशषഃٙ೯͛ձ೯࢝fઞ॰
ߤ
ٙᄣಟཀdʔස࿁Ⴉᗆ͛նՈϞɤʱࠠ
ࠅ
ٙଣሞจ່dɰ
މ
ᐞ͍͛նତ̰ፅًٙ࿒dνᗫशषԣ
ط
dԶࠠ
ࠅ
ٙଣሞԱኽf
2.
ᅲʔᄣಟ
ߤ
;၈א
े
ߤ
e᎑ࢹ
ߤ
e
G0
ಂ
ߤ
fᅲࣛ୭ᕎಂd
G1
ಂ̈Ըdʔආɝ
S
ಂd
৾वί
G1
ಂfϞԬϓᜄၪ
ߤ
ఱ݊
G0
ߤ
dաՑ
ቇՐዧࣛdࠠอආɝ
G1
ಂd್
ܝ
ʱᄣಟfӿ
ᛔ
ߤ
Ύ͛ɢ
ܘ
੶f
3.
ʔΎᄣಟ
ߤ
၈א
ʔʱ
ߤ
eʔԃ
ߤ
e
͋ʱ
ߤ
νग़ʩ
ߤ
eൖၣᇫ
ߤ
e
ڌ
ͤ
ߤ
e̻Є
ߤ
e
ߎ
ߤ
ഃf
細胞週期調控的分子機制
ίε
ߤ
ॆࣨ
ߤ
͛
ي
ʕdਞၾ
ߤ
ಂሜછٙࣨ
ːஐͣʱɿ
މ
3
ɽᗳdʱй݊j
1.
ಂஐͣԱ፠ዧ
㺛
(CDK)
e
2.
ಂஐͣd͵၈ಂ९
(Cycline)
eʿ
3.
ߤ
մಂ
簡志瀚 Kan Chi Hon
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