52
၍dࠥЭА૰ᓂະ
ܓ
dᄣ̋
ڿ
ًਗএА
ݴ
ඎd
ڮ
ආ
ˏৎАᏀʺ৷ٙඒഃ
ي
ሯٙર
د
dΪϤ݅ঐሜື
АইdᒔϞࠥЭАᏀձཫԣАࣼҖϓٙЪ͜f
ԸdභʕቇආɓԬ
ݱ
ᇼdʔ̰
މ
̂
PGA
ٙ
ɓ
ࡈ
λࢰf
੬ΦᇼeᑞeႉeჂಕfɰϞಯˇ೯
ف
ٙ̌ࣖf
Ϥ̮dฆඎٙቔeᒝeၪ͛९
C
ʿ
B6
̙
ڮ
ආ
PGE1
ձ
PGE2
ʘ͍੬Υϓf
前列腺素臨床應用探索
ҵՓ
ۃ
ΐ໗९
•
ط
ᐕ࿔ष
ݭ
ช
ݑ
f
ߕ
߅ኪ௰
ڐ
ɓධӺ
ڌ
d࿔ष
ݭ
ช
ݑ
ν
HIV
ഃึኬ
ߧ
ݭߤ
T
ˋ
ߤ
̌ঐসৗdԴष
ݭ
˸ίɛlzໍဳdίவ
ࡈ
ཀʕ
PGE2
ᗫ
ڦ
ஷ༩೯౨əࠠ
ࠅ
ٙ
ڮ
ආЪ
͜fΪϤdҵՓ
PEG2
א
݊
ط
ᐕ࿔ष
ݭ
ช
ݑ
ٙϞ
ࣖ˓
ݬ
(2015)
f
•
ط
ᐕ೯
ف
e೯ᆠe़೨ഃˀᏐٙʔቇfவԬʔቇ
݊Ϊ
ۃ
ΐ໗९ˏৎٙd͜
ڛ
ʸ؍ҵՓ
COX
d
ϾҵՓə
ۃ
ΐ໗९ٙЪ͜fʔቇ̙˸ᇠ༆f
•
ط
ᐕ᎘೨f᎘೨೯ЪࣛdΪА૰ʕ
PGE1
ўඎ
ʺ৷dኬ
ߧ
҅໘А၍ᄌडᓒੵձ⚞ਗష
ܓ
ᄣɽ
ߧה
f
ڛ
ʸ؍ʍᓔଡ଼ᔌʕ
PG
ٙΥϓd݂࿁᎘
೨Ϟɓ֛ٙᕄ೨Ъ͜f
•
ط
ᐕɾ೨fɾٙ೨dɽʱ݊͟
ۃ
ΐ໗
९ˏৎٙfΪɾԸ˜ࣛdίშዧ९ٙЪ͜
ɨdɿlzᇫᄣ
ێ
dίϤཀʕึପ͛
ۃ
ΐ໗
९f
ۃ
ΐ໗९ˏৎɿϗᐵdϾኬ
೨ߧ
f
Ꮠ͜
ۃ
ΐ໗९
•
治療哮喘、紅斑狼瘡、關節炎等炎症疾病。
•
預防血管疾病和中風。
•
治療罕見的先天性心臟病。
•
引產。
PGF2
Ъ͜ପˏପf
•
治療癌症。
PGA2
א
PGE2
̙ঐႰ೯ɓԬАᐖ
ߤ
ٙʱʷdʔΎᘱᚃ͛
ڗ
dϾҵՓᐖ
ߤ
ٙ͛
ڗ
f
•
治療青光眼。
ஷཀ
PG
ဈ૰׳ᕦ౹մఖЄЂʿ
ಯჀ
ف
सf
•
治療勃起障礙。
PGE1
ஷཀԴlzٙЄЂ׳ᕦձ
А૰ృᐑනdϾᐏԑ˸ኬ
ߧ
ۉ
ৎٙА
ݴ
f
•
幫助急救血管損傷時引起的出血。
̙Σत֛ฦෆ
З
ء
࢛
PG
ᏍпኑАf
•
預防及治療胃潰瘍。
ߞ
ᓂᇫ˴
ࠅ
Υϓ
PGE
dஷཀ
ಯˇ
ߞ
ʕٙა
ܓ
ԨՐዧᓂ૰ٙପ͛f࿁
ߞ
ᓂᇫϞ
ڭ
ᚐЪ͜d
ߞ
ᓂᇫ߰ॹ˶
PGE
ۆ
ኬ
ߧ
षฦf
Prostaglandin & Health
Structurally, different Prostaglandins (PG) exist, e.g., PGE, PGF: for uterine contraction (labor induction); PGE1, PGE2: for gut muscle
contraction and motion; PGE: relaxes bronchial muscles in asthma; PGE2: regulates blood pressure; PGE2 regulates temperature and
fever: aspirin reduces fever by inhibiting PG synthesis; PGE2, PGI2: intimately related to inflammation and auto-immunity (tissue
self-destruction); PGE2 increases inflammation (if linolenic acid intake inadequate); PGE2 is for immunity; PGD2 and PGE2 together
regulate sleep. For optimum PG function: take more Omega-3-rich food, e.g., salmon, tuna, mackerel, herring and halibut, etc. and fish
oil but less food with Omega-6; onion: lots of PGA, a strong blood vessel dilator, also softens blood vessels, reduces blood viscosity;
take more spring onion, ginger, garlic and pepper. Clinically, PG is for chronic viral infections, e.g., AIDS: using PG2 inhibitors; using
aspirin to inhibit COX to reduce effects of PG; as migraine is associated with PGE1 excess and aspirin interferes tissue PG: good for
migraine; menstrual pain is also related to PG excess. Other uses are: asthma, lupus, arthritis, cerebro-vascular diseases, stroke,
congenital patent ductus, labor induction, leukemia, glaucoma, peptic ulcer, erectile dysfunction, etc.
專題探索
