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ASPIRIN AND REYE'S
SYNDROME
Reye's
syndrome
is
a
potentially
fatal
disease described
in
1963
by
Reye, Morgan
and
Baral: acute
brain
swelling and degenerative changes ol
the
liver.
The peak incidence
is
between
4
months
to
16
years, probably due
to
the
immature
state of these
organs,
especially
the
blood brain
barrier
(protecting
the
brain
from
obnoxious
substances).
ln
UK alone, there
were
100
odd children dying from
Reye's
Syndrome.
Although aspirin
had been
a very effective and useful drug
for
control of fever and pain, the discovery
of aspirin precipating
Reye's
Syndrome
lead
to the
prohibition
of
aspirin
for
children under
the
age
of
16. Even
though
the
main
culprit
is
viral,
after
taking aspirin
for
about
a
week, suscep-
tible
children would
develop
the
Syndrome
-
a
combined
effect of the
virus with aspirin. Symptoms are
fever,
headache,
running nose,
cough,
tiredness, severe and frequent vomit-
ing leading to dehydration (serious lack
of body water), acidosis (too much acid
in the
blood),
blood electrolyte
imbalance,
liver
function derangement.
Uncontrolled,
the child
goes
into
jaundice, delirium, coma, convulsions
and even
death.The
risk of death
is as
high
as
42"h
in
some series.
Even
those
recovering may have residual
brain
damage. All parents and child-care per-
sonnel
should
take good
notice of
this
Syndrome.
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