60
ᓯҁᕲ
ઠ˚
ܛ
.DQ &KL +RQ
ၝΥజኬ
ᛘ٫
ڦ
ᇌ
ᇁፎͱ́iʌˀ௩ၘਝɍΊޫነࡼንဲଶ㢓
ޢ
Ӡྔ
2009
αጻӴဍᔢነᆉe҈ཋ
഼ຝ͌ɺϢඨ႓ɻcȹωᚹԷဲଶ㢓ΊീcԷ
ࠋ
́ณթeᘗ
ڬ
ɌΕܱ
ࢌˀం
ޜ
Էcᗐ
כ
ඔ٠ॶқԹဲଶ㢓
ݠ
ֲcϤνԷқԹົᆔ́
ٽ
ࢽ
ؿ
ం༞e҈ܰ
ȹᏼटన౨
ؿ
ञɁc̳Ε
ࠕר
ඔ٠c
ܨ
ʹȹωԚ҈ྦྷဲଶ㢓Է
۾
ɣ
ؿ
ጙመeϤʌ
ҡᏵ੪ဲଶ㢓
ޢ
ӠᏵᆉcҡܰጙኍୣΊeΐϊऋԲᇼઠi
ޅ
ფܰဲଶ㢓j
ޅݯ
ფқԹȿ
̚
ݠؿ
ֲగ˿˞
ڂ
қົᆔ
ؿ
́
ٽ
jඔ٠̔cᑹτԅԒɻᖞֶϹᖞɖॶқԹဲଶ㢓
ݠؿ
ֲjᐽѷɐᎶ͂
کؿ
ౡΣЄjᑢᑢe
ᚾّ ณຏɐ
2009
α
10
˂
6
ˀ
ဲଶ㢓
(telomerase)
߬ȿဲଶ㢓cࠖͱ߬
ע
͉
ޅ
ფܰဲଶ
(telomeres)
e
ဲଶ࿚˳
ܢ
ဲଶ
DNA
ဲଶ୶͉eဲଶϽ
כ
भ࣏́
ذ
ܷϳ
ؿ
̱ဲ
(
Ӯ
྇
)
eဲଶగཫ
DNA
ړؿ
ᙶຫc̚
ࠇ
߬
ؿ
А͂గܰ
ړ
ᙶട
DNA
ЛՇዱฌcԚ
ࠇ
߬
ڌؿ
ࢠɺผ͕̖eѧኬ
ؿ
ဲଶ፭ടୀ
ߋ
ҰωʗഹϤᛰcԷܺೡ۹ୀ
ߋ
ੀɺ
ʹʗഹeୀ
ߋ
గผᛰঞϢֶ
ࡀ
əe
ဲଶ㢓ܰȹိᔝ፣㢓cܰȹိͅ
RNA
ၤ୶͉࿚ι
ؿ
࣏ጅ࣏୶͉eЩ̚˿
˞Ήဲଶ
ࠇ
ᰛ˱
DNA
ѵͶc˞ԉୀ
ߋ
Εʗഹ༦ೡɻฌ̖ፘඨ
ڌ
ࢠeֺ˞cဲ
ଶ㢓Ԯτྦྷဲଶ
ؿۺࠇ
А͂eΕ߄
ߊ
෦ୀ
፼೩ߋ
ᐥʗഹ
ؿ
ୀ
ߋ
ʑcဲଶ㢓୮
ݠכ
ᙺ
ر
ྸeЎΕ̳ιαɁcడ˝ֺτୀ
ߋ
ɻ
ؿ
ဲଶ㢓ᔝ
ݯ
ͤम
ر
ྸe
Ꮠ͜
౻ۃ
ͅ
כ
ဲଶ㢓ܰົᆔ؝ᏻ
ؿ
ȹཐᒨcΛိဲଶ㢓қԹቸἙ৽
ذ
ɻ˿қԹဲଶ㢓
ݠؿ
ֲc႖ኒୀ
ࡀߋ
əe
ܨ
Ꮆτ
۾
Ρ
ؿ
Ꮆ͂
ک
ౡeЎʋ߬ҡΛ
ؿ
ᐽѷᖬeτ
ޢ
Ӡّႏ
ݯ
cဲଶ㢓қԹቸ
ؿ
А͂ܰᇅྺ
ؿ
cʋ
ၤԯˢҊᏼʿؒᐲԚ͂e̚ԯ̚Ҋᏼᖞȹᅚcɖ˿˞ଐ́ᖞֲeϊ̔c͌
ک
ᑹॠ˜ણ۹dऋଔ
ֲঢ়
ؿ
ց൴ᆢ
ؿ
Ꮞಡဲଶ㢓
ݠ
ֲ
ؿ
ʿؒeܰᐽѷᎶ͂
ؿ
ᗐᒄeΐϊcဲଶ㢓
ޢؿ
Ӡᑹτ
༏ؿٽ۾
߬Ӷe
ဲଶ㢓
ၤ
ඔ٠
྇ ဲଶ͐෮྇
ඔ٠ܰȹိဲଶ㢓қԹቸ
ඔ٠А
ݯ
ȹိҊᏼႤХᖞ
ذ
cԯА͂ɰԷٛցeȿ̚ॶ
ق
અА͂
כ
ົᆔ̯Ӹ̔c̚ᑹॶొʠЛ
ދ
˲ॶ˞
Сྦྷᏼୀ
ؿߋ
ࣱeณ
ٶ
ҡτ
ޢ
Ӡّׄᚉc
ޢ
Ӡೕଊඔ٠ᑹܰȹိဲଶ㢓қԹቸeᎶ͂
כ
ӥᏼɩལӸɐ
ࣂcೕଊඔ٠ॶτࢽ
ࠌ
Гɩལӥᏼୂᓱɻ
ؿ
ဲଶ㢓
ݠ
ֲcྦྷɩལӥᏼଐ́
ؿ
қԹଅঢ়༠ȼι˸eᎶ͂
כ
τϨ
ᆔ
ؿ
ɩལӸɐc͛༠ȼιқԹА͂e
ԯ̚ᑹτం༞i
ߕ
⮈ᜣྦྷӥᏼ
HepG-2
ୀ
ߋ
࣡hᴢᒗ
(AS2O3 )
ྦྷӥᏼ
HCC-9204
ୀ
ߋ
࣡dྦྷɁЪੑᏼ
HO9810
ୀ
ߋ
࣡hএΛ−ྦྷ
BEL-7402
ୀ
ߋ
hᇲʿˬ
࠾
উ͆ॖྦྷْᏼ
SPCA-1
ୀ
ߋ
࣡hͅ↭̮d˸
ײ
ᇘdࣜ߈೩ୂι
ؿ
ᇲ
ʿྦྷືᏼୀ
ؿ೩ߋ
ဲଶ㢓
ݠ
ֲяτȹցқԹА͂e
፳
ټ
ޢ
ӠɁ
ࡗ
cС͂ፘඨɮೡқԹဲଶ㢓
ݠ
ֲcԚԯܷϳ̱ဲ
ؿ
ဲଶᛰcԚɩལ϶ᏼɺผˮଊe
ဲଶ㢓ܰᏼୀ
ؿߋ
ȹိᅟႌ
ୀ
ߋ
ೕ́ᏼᛰ܃cဲଶ㢓
ݠ
ֲˈ̳ࣂ
ע
ᛷᄈঢ়c̚ॶਪΕܷϳѮဲ˱
DNA
cᏼୀ
ߋ
ʗഹࣂcܷϳ
ᐛcဲଶ㢓గผ˱ΑȹᒨԞeֺ˞ᏼୀ
ߋ
˿˞
ٽ
́ɺϋeΐϊcȹ̭Ґົᆔୀ
ؿߋ
ဲଶ㢓
ݠ
ֲқԹcగผԚᏼୀ
ߋ
ӶΉϋəe˿Ӯcဲଶ㢓
ݠؿ
ֲܰᏼୀ
ؿߋ
ȹ
ࠇ
߬ᅟႌcΐ
ݯ
ဲଶ㢓ၤ
90%
ؿ
Ɂົᆔ
ޚ
ᗐc
ܨ
˿˞А
ݯ
ᏼट؝ᏻɻ
ؿ
ȹཐɥe
ဲଶ