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Chen
Fu
Clian
GENE
FUNCTIONS
AND
RESEARCH ON DISEASES
Gene
mutations
are
largely
responsible for diseases, as confirmed
by
the
Chinese National
Genome
Center
sequenced
127 known genes
on
chromosome 21
from
human
and
chimpanzees:
lound
3003 differences.
The
Epigenomics AG in Berlin and the
WelcomeTrust Sanger lnstitute
in
Cam-
bridge are detecting
DNA methylation
patterns, the
"on"
and "off"
signs for
genes,
to
improve management ol
cancer and other diseases. ln
USA,
the
level of high-density lipoprotein had no
insignificant ditferences between
1
00-
year-olds and other controls; but, 80%
of
these elderly
have
larger lipoproteins,
making
them more difficult
to
enter
vessel walls
to cause
hardening; also,
25%
(vs
8% controls)
of
them
had
defects
in
the cholesterol ester transfer
protein (CEPT) gene that turns
good
HDL into bad
LDL.
Japanese workers
now
successfully utilize
anaerobic
(oxygen independent) bacteria genes
to deprive cancer cells of oxygen; they
also combine the genes of a flu virus
with telomerase
to "infect"
the cancer
cells experimentally. ln USA, weakened
genes from
a
flu
adenovirus are injected
experimentally and achieved 60% cure
rates for
a
brain malignant glioma
in
animal studies.
The author
also
reported
injection
of a recombinant
human p53
gene adenovirus
has achieved
64"/"
complete remission rates in squamous
cell head and neck cancers
in
Shenzhen.
The
potential
is
tremendous.
1.
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