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sETAH
Zhang
Gliu-Zhen
HOW
TO CANCER CELLS
METASTASIZE?
The
basic mechanism of tumor
Invasion is not fully
understood.
Me-
tastasis may occur
in
the vascular or
lynphatic
system.
However, tumor cells
are more
likely
to mestatasized through
vascular
pathway.
Certain experimen-
tal
tumors produce proteolytic enzymes
or
collagenase
(such as
collagenase
lV)
which
may
destroy or
modity adjacent
tissue
collagen and
facilitate
metasta-
sis.
ln addition, tumor cells have de-
creased
their
cohesiveness as com-
pared
to
normal
cells and
may readily
detach themselves from the main mass
and
exfoliate.
Small detched clumps
of
tumor cells are much
more likely
to
produce metastatic
foci
than
single
cells.
Such cells adhere to the vascu-
lar endothelium of a small post capil-
lary,
initiate
librin formation
, multiply,
and invade the endothelial defects.
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24
