80
ϼཽਗ਼࿁ᚤ
ڥ
ٙᑊࠪʔପ͛ࢵᙰชfவ၇˙
ج
ၾ߅
ˌཥᅂ
ߕ
ᘆːᜳٙ͑㛬ජΈʕ݂ٙԫઋືɤʱ
Чf߅ኪਗ਼வධӺజѓ೯
ڌ
ί
ڐ
ಂ̈
و
ٙ߅ኪ
Ҟజɪdᑊ၈வ࿁͛
ݺ
ίࢵᙰʘʕٙઃ٫ՈϞࠠ
ࠅ
จ່f
༈ධӺ
ࠋ
பɛଣ
ݟ
ᅃ
-
;̵̋
ဧ
(Richard L Huganir)
௹ɻႭj
¨ɓϣ೨߮ᗭҙٙ௴ෆʘ
ܝ
d
ਗ਼Җϓܵᚃ
ࡈ
͛նٙࢵᙰা
ኳd
٫א
ኬ
ࡈߧ
ɛ͛
ݺ
ᜊɤʱ
ൈࢮfҢ
ࡁ
ٙ௰อӺ೯ତਿ
ɓԬஐͣሯʱɿձ
ߤ
ዚଣ̙
Ⴁอۨᄣ੶Б
މ
ط
ᐕᖹ
ي
d͜
ط
ᐕ௴ෆ
ܝ
ٙၚग़̰ሜf©
Б
މ
ᐕ
ج
̙ᇠ༆ઃ٫ٙઋၫd
ԨಯჀ೨߮௴ෆٙাኳdШʔঐ
ҁΌмৰাኳ͉Ԓf;̵̋ဧձ
௹ɻ
ܝ
Νԫᖯ௫
-
дཤ֍
(Roge r
Clem)
ߧ
ɢӺ
ܯ
ࣹٙग़
ၣ༩d༈ɽ໘ਜਹ
ࠋ
பછՓɛᗳ
ձਗ
ي
ٙࢵᙰૢЪ͜fԴ͜ᑊ
ࠪԸ
ط
ᐕϼཽٙࢵᙰd߅ኪᝈ࿀೯ତ
ܯ
ࣹٙ
ݔ
Ԭ
ߤ
ਗ਼Դϼཽһቇ֝ᅳᚣᚤ
ڥ
e߉್ٙᑊሜᐑ
ྤf
ίϼཽஈኛࠪᐑྤٙྼ᜕ʕd˼
೯ࡁ
ତɓ၇သீ
එٙतࣿஐͣሯ{{
AMPARs
ਗ਼ᅲࣛήᄣεdவ
Ԭतࣿஐͣሯ
੬ڢ
ʔᖢ֛d̙ग़
ߤ
ʕৰf
;̵̋ဧ௹ɻႭj¨Ң
ࡁ
ٙ˙
ج
݊ৰவԬஐͣሯd
ۂ
ࢮ௴ෆኬ
ߧ
ٙɽ໘াኳᗡഐdϾмৰাኳ͉
Ԓf©ίટɨԸٙྼ᜕ʕd˼
೯ࡁ
ତஷཀʷኪҷԄ
GluA1
ஐͣሯd
̙˸ৰ
AMPARs
ஐͣሯf
˼
೯ࡁ
ତॹˇʷኪҷԄ
GluA1
ஐͣሯٙྼ᜕ϼཽਗ਼
ܨ
ూܼ̍ྜྷ
ᕏᑊࠪ
੭ה
ԸٙࢵᙰাኳdШ݊
̈͛ٙʃϼཽ
ۍ
ʔึ
ܨ
ూவᅵ
ٙࢵᙰাኳf
;̵̋ဧႩ
މ
dႡɓ၇છՓձ
ᄣ੶එသீ
AMPARs
ஐͣሯٙ
ᖹ
ي
̙͜мৰাኳdவᛓৎԸ
ϞᓃՅ྅߅ˌཥᅂٙઋືd፯
ήৰɛᗳাኳf͊ԸϞɓ˂
̙Ꮠ͜
ط
ᐕՈϞࢵᙰাኳٙɛ
໊dˢνjԟԬቊա
ن
eၚग़
ձԒ௴ෆٙ௴ෆ
ܝ
Ꮐɢːଣღᖟसઃ٫f
綜合報導
Ӻɛࡰ೯ତɓ၇͑ɮмৰাኳٙ˙
ج
d
א
ਗ਼
ઃ٫੭ԸҎૐf
The Brain Plays Jig-saw Puzzle: Scientists Propose New Theories on Memory
The Encoding Variability Theory was proposed by psychologists 40 years ago to enhance our understanding on memory. According to
this Theory, there is a spacing effect due to different contexts during memory encoding, which result in repeatedly studied items being
encoded differently into memory on each repetition. The more of these different encodings there are for the item in memory, the easier
the item is to be remembered. But, Russell Poldrack of the University of Texas, using functional magnetic resonance imaging (MRI)
images refuted this theory, even though Marvin Chun of Yale University disagreed with the interpretation. Rick Henson of the MRC
Cognition & Brain Sciences Unit, Cambridge University also backed the Theory. At the Johns Hopkins University, Richard Huganir and
postdoctoral fellow Roger Clem discovered a “window of vulnerability” as unique
α
-amino-3-hydroxy-5-methyl-4-isoxazolepropiomc
acid receptor subunit (AMPARs) proteins occurring temporarily in the brain for memory can be destroyed by a medication enhancing
calcium permeability: very useful to erase traumatic memories, just like in the movie, “Eternal Sunshine of the Spotless Mind”.
醫學新知
