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Ho
Chung
-Yin
The
outbreak of SARS
in
Hong
Kong originated
from
a professor from
southern China,
who
had traveled to
Hong
Kong
on February
2
1
,
2003.
Two
anicles written
by
the clinicians and
re-
searchers
at
two major universities
in
Hong Kong are among
the
earliest
worldwide SARS clinical reports
pub-
lished in international medical journals.
These two articles
are
valuable
to the
subsequent treatments and researches
on
SARS in
the
world. We
herein
summarize,
based on the
two
articles,
the
clinical,
radiologic and laboratory
features of
the
first cluster of
SARS
patients in Hong Kong. The most com-
mon early symptoms
at
presentation
were fever,
malaise,
chills,
headache,
myalgia,
dizziness,
rigors, cough, sore
throat and diarrhea. Moreover, inspira-
tory crackles were heard. Other
com-
mon
findings included
leuokopenia,
lymphopenia, thrombocytopenia
and
elevated serum
lactate
dehydrogenase,
creatinine and
alanine transferase
levels. Chest X-ray findings typically
showed
unilateral
or bilateral
shadow-
ing and
in
the deteriorating or severe
cases, the shadowings progressed
to
become generalized with
interstitial
infiltrate.
Microbiologic
and
virologic
tests
revealed no evidence of iniection
by known bacteria or
virus.
The lreat-
ment of
choice was ribavirin
in combi-
nation with corticosteroids, which
ap-
parently are responsible for some clini-
cal improvements
like resolution of fe-
ver and
lung opacity,
and partly
resto-
ration
of
hematological
parameters.
However, despite treatments,
some
cases deteriorated rapidly with
low
oxy-
gen saturation and
acute
respiratory
distress,
and required ventilatory
supports.
A few
aggravated cases died.
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56
