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order to improve
insulin
therapy for diabetes mellitus,
speciatists
in
the
1960's
successfully
developed
pancreas
transplantation which
can
substitute
for
insulin
therapy.
However,
pancreas transplant
has
many
probtems
which
are
still
insoluble.
Recently colon or oral method are introduced to
atteviate
unnecessary inconvenience and
pain
caused by injection.
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