56
ԭၚᶶ
(spermidine)
f
ԭၚᶶϣ݊ίၚ૰ʕ೯ତ
ٙdԨΪϤϾնΤfԭၚᶶɰπίɓԬ
ي
ν
ϓᆞԪ
(Hard cheese
d
ٺ
ɻ
)
eጋ⊵eԌᗳձΌಠ
ي
ഃʕfෳήлӺɛࡰజѓ
(2016)
jਗ਼ԭၚᶶ̋ɝ˥
ʕᒸཱϓᆞٙϼཽd೯ତԭၚᶶ̙˸Ⴐኬϼཽٙː
Є
ߤ
ІአЪ͜dԴʘરৰːЄʕɓԬ̰̘̌ঐձ
ೌ̀
ࠅ
πίٙʱdᄣ੶əːЄٙ̌ঐdАᏀࠥЭd
ආϾ
ݺ
һ
ڗ
ɮf
༶ਗf
ߕ
ɓ
ࡈ
Ӻʃଡ଼d
މ
ə᜕൛༶ਗνО৷
ɛٙІአЪٙ͜ዚՓdӺɛࡰਗ਼ɓଡ଼ʃཽਂਿ
ΪҷிdᜫՉlzٙІአ೯̈ፃΈၠЍdᝈ࿀೯
ତʃཽίཀə̒ʃࣛٙൺӉዚ༶ਗ
ܝ
dՉЄЂʕ
ٙІአᄣ̋dԨ˲ঐܵᚃᄣٜ̋ЇൺՑ
80
ʱᙒf
ط·
ᐕᐖसj
ᜳ
ٺ
f
̨ᝄٙӺ൛ྼ
(2015)
dԸІʃᥗɿᜳ
ٺ
ٙе
ޥ
ሜືஐͣ
GMI
d̙˸ίlzձ઼̮ਗ٬ᐖ
ߤ
І
አዚՓdᜫᐖ
ߤ
ІҢəᓙϾҵՓ໕ᆯٙ͛
ڗ
f
Ԩ̙৷නཔٙᐕࣖdԴ٬ᐖ
ߤ
Іአၾ࡙ɳՇ᎘
ደf
̆Ӵ㹷
B
f
̆Ӵ㹷
B
݊ʕᖹ̆
ה
ўϓʱfྼ
᜕ഐ
ڌ؈
d̆Ӵ㹷
B
̙Ⴐኬɛ᎕ᐖ
HeLa
ߤ
ІአdԨˏৎІአᅺႦஐͣ
Bec l i n -1
༺ڌ
ᄣ̋ʿ
LC3
ŗᔷᜊ
މ
LC3
ŘiІአҵՓኒ
3-MA
ʔШ̙˸ҵՓ
༈ІአЪ͜dϾ˲˷ҁΌᔷՉҤᄣಟЪ͜d
ͪՉ͛
ڗ
ҵՓЪ͜
މ
ІአԱ፠ٙf
߮ਞf
߮ਞ݊ʕᖹ߮ਞʕ՟ٙ͛
ي
fྼ
᜕൛d߮ਞ̙Ⴐኬ
ߞ
ᐖ
SGC-7901
ߤ
Іአf
ط·
ᐕ
ږݡ
Ⴥसj
ནᖸf
ʕᖹནᖸ̙ҷഛ
ږݡ
ჅसषઋfΪནᖸʕў
Ϟɓ၇ମནᖸٙ
ي
ሯd̙ίग़
ߤ
ႰኬІአ
Ъ͜d̋Ҟৰ
ږݡ
Ⴥसጐၳٙ
ߧ
षମ੬ஐͣf
Ϥ̮dঐႰኬ
ߤ
ІአٙʕᖹᒔϞjරҊ㹷eᖿ╵
ᜳe۴ර९e
ڡ
ႃ९eͣ᎘ॽӴ㹷ഃf
µ
ҵՓ
ߤ
ІአЪ͜
ط
ᐕशष
ط·
ᐕᐖसj
Ѐၷf
݊ʕᖹЀ՟
ي
fঐஷཀɨሜ
mTOR
ڦ
ஷ༩dҵՓɛ٬໗ᐖ
ߤ
ӻ
A549
ߤ
ᄣಟdԨ
Ⴐኬ
A549
೯͛ІአfШᑌΥԴ͜ЀձІአҵՓኒ
3-MA
̙ঐһϞࣖ೯౨ЀҤ໕ᆯᄣಟЪ͜f
Ϥ̮dঐҵՓ
ߤ
ІአٙʕᖹᒔϞjԔe͞ɖeʇ
ᣡ㹼ഃf
۲ྐྵf
̻੬͜
ط
ᐕဳशٙ۲䄑d݊ɓ၇
ߤ
Іአ
ٙҵՓኒfਗ਼۲䄑ձ੬ٙ͜ʷᐕձᅺཪᖹ
ي
ഐΥৎ
ԸdҵՓᐖ
ߤ
Іአঐɢd࿁
ط
ᐕɓԬϞ
ߗ
ᖹٙ
ᐖसd
ڋ
ӉԸϞɓ֛ࣖ
؈
f
ط·
ᐕᜤⶶ
ಭਟ
ڡ
ብ९
(Wortmannin)
f
݊ɓ၇ІአҵՓኒfঐ
तମҵՓ
P13k
dʍᓔ
ڜא
ᓙІአٙҖϓfᜤ㹲
೯Ъኬ
ߧ
ٙऎ৵ฦෆࣛdπίІአዧ
ݺ
ତdಭ
ਟ
ڡ
ብ९ঐஷཀҵՓІአ
ݺ
dಯჀᜤ㹲೯Ъ
ߧה
ٙऎ৵ฦෆfՈϞ
ڭ
ᚐग़ٙЪ͜f
Autophagy & Health
Akin to housekeeping, autophagy increases with aging. Tumors are initially inhibited but eventually survives; nasty cancer cells use
it to promote adaptation, eg, chemotherapy resistance. In Parkinson’s, glucocerebrosidase (GBA) gene mutation leads to
α
-synuclein
accumulation; in Alzheimer's,
β
-amyloid peptide accumulates. Though killed by autophagy, the tubercle bacilli (TB) can also exploit
autophagy for protection; though the hepatitis B virus is killed by autophagy, the Zika virus may activate abnormal autophagy affecting
fetal neuro development. Promotion of autophagy: (1) Polyphenols in coffee: sustained autophagy in mice liver, heart and muscles
(2) Spermidine (from hard cheese, mushrooms, beans and whole cereals): autophagy in mice heart muscles: with “tidying up”,
strengthening, blood pressure lowering and longevity (3) Physical exercises: sustained autophagy (4) Lingzhi: autophagy (mice and
petri dish) in lung cancer cells: suicidal effect; cisplatin chemotherapy also enhanced (5) Maidong extracts: autophagy in human
cervical cancer cells (6) Bitter ginseng extracts: stomach cancer cell autophagy (7) Cat’s claw (uncaria) improves Parkinson’s disease
symptoms. Inhibition of autophagy: (a) Huaier extracts on human lung adenocarcinoma cells (b) Quinine: combo with chemotherapy or
targeted therapy (c) Wortmannin: neuroprotective in post-convulsion brain damage.
專題探索
