52
白細胞介素與健康
從T淋巴細胞說起
ҁϓʱʷٙ
T
ߤ
ʱϓ̙ʱϓɧᗳdуࣖᏐ
T
ߤ
(TE)
eሜື
T
ߤ
(Treg, TR)
ձাኳ
T
ߤ
(TM)
f
T
Ⴞп
ߤ
(Th)
ίɛlzdе
ޥ
ӻ୕ٙ
T
Ⴞп
ߤ
(T helper cell, Th)
̙
˸ʱ
މ
Շᗳjୋɓۨ
T
Ⴞп
ߤ
(Th1)
d˴
ࠋࠅ
ப
ߤ
е
ޥ
dၾഽष
ݭ
ช
ݑ
शषe໕ᆯձኜ֜ಔഃ
ٙˀᏐ༰ϞᗫfୋɚۨႾп
ߤ
(Th2)
d˴
ࠅ
࿁͛
Џପ͛Ъ͜f
ࠋ
பཀઽˀᏐf
ڐ
ϋϞɛ̈ə
Th1
e
Th2
e
Th3
e
Th17
ձሜື
T
ߤ
(Threg)
ٙ฿ׂj
ThI
ۨ
ߤ
Ϊɿ
ڮ
ආ
ߤ
ʧኬٙе
ޥ
Ꮠഈi
Th2
ۨ
ߤ
Ϊ
ɿ
ڮ
ආ૰е
ޥ
Ꮠഈi
Th3
ۨ
ߤ
ΪɿʧኬҵՓе
ޥ
Ꮠഈi
Th17
ۨ
ߤ
Ϊɿʧኬ
ف
सˀᏐf
ሜື
T
ߤ
(Treg)
ሜື
T
ߤ
(Regulatory T cell, Treg)
ɓছʔΝࣖ
Ꮠ
ߤ
dஷ੬ʔ࿁ҤࡡٙՐዧٜટˀᏐdϾ݊˸ࣖᏐ
މߤ
Ъ͜࿁dሜછ
٫ܝ
ʧኬٙе
ޥ
Ꮠഈfᒱ್Ϟ
ɛႩ
މ
d೯౨
ࠋ
ΣЪٙ͜
T
ߤ
dɰఱ݊ҵՓ
T
ߤ
( Ts)
dίˀ㉿ሜືʕdኽϞࣨːήЗfШሜື
T
ߤ
ʔ̥ঐ˸ҵՓٙ˙όሜືе
ޥ
ˀᏐd
ה
˸ˢৎ
ίе
ޥ
ӻ୕༶ЪٙཀʕdϞԬਞၾͣ
ߤ
ගʝЪ̙ٙ͜๓ʱɿd၈
މ
ͣ
ߤ
ʧ९
( i n t e r l e uk i n , I L )
dᔊ၈ͣʧ९fͣʧ९ձՉ
̴
ߤ
ପ̙͛ٙ๓ʱɿd୕၈
މ
ߤ
Ϊɿ
(Cytokine, Ck)
f̴
ࡁ
εᅰ݊ɓԬЭʱɿඎٙᒙஐ
ͣf
ߤ
Ϊɿʝϓɓ
ࡈ
ၣഖdঐᅂᚤе
ޥ
ߤ
ගٙБ
މ
ၾतᅄf̴ఱ྅ʹᚤᆀྠܸٙ౨ಏd
ঐᗅϓе
ޥ
Ꮠഈٙ҃ɽᆀd݂Ϟе
ޥ
ӻ୕ᜳ
჻ʘ၈f
ڐ
ϋԸdһ͟
ߤ
Ϊɿdܼ̍ͣʧ
९Ӻٙ߉ॎආ࢝dᜫҢ
ࡁ
һආɓӉə༆Ց̴
ࡁ
ίੰၾशषගҲစٙԉЍd
ޟ
Їක઼əɓԬ
࿃อ
ڭ
ձ
ط
ᐕٙɽ
ژ
fอ
ڐ
(2016)
࠰
ಥ߅ɽ೯
ҵՓd၈
މ
ሜື
T
ߤ
ˢ༰ΥቇfΪϤ
މ
əᒒе
૿ଌdҵՓ
T
ߤ
ʉ
1990
ϋҷΤ
މ
ሜື
T
ߤ
f
ሜື
T
ߤ
˴
ࠅ
ʱϓՇᗳjІ್ሜື
T
ߤ
ձቇ
Ꮠሜື
T
ߤ
fІ್ሜື
T
ߤ
ٙ˾
މڌ
CD4+
e
CD25+ T
fՉ̌ঐ݊ҵՓІԒˀᏐ
T
ߤ
ʧኬٙ
҅ᏐഈfቇᏐሜື
T
ߤ
ٙ˾
މڌ
Tr1
e
Th3
e
CD8+ T
fՉ̌ঐ݊ҵՓІԒฦෆ
ف
सˀᏐe
ڜ
༿
षࡡձಔ
ي
ˏৎٙषଣᏐഈf
細胞因子
ᒱ್
ܘ
ε၇
ߤ
ѩ̙˸ʱ
ؤ
ߤ
ΪɿdШՉʕ˴
ࠅ
ϞՇ၇
ߤ
dу
T
ߤ
ձ̶አ
ߤ
dतйˏɛ
ء
ͦd
̴
ࡁ
ᙑ׳ٙ
ߤ
Ϊɿdਞၾ
ߤ
е
ޥ
e૰е
ޥ
e
ف
सˀᏐeிАሜછe
ߤ
ᄣಟʱʷeฦෆ
ࡌ
ూഃ
ࠠ
ࠅ
͛ଣཀf
ߤ
Ϊɿٙ̌ঐ݊ஷཀཪ
ߤ
ٙաഐΥdஷཀ
Νᔷኬᗡෂዧ
ڦݺ
dପ͛त֛ٙ͛
ي
ኪࣖᏐf
ͣ
ߤ
ʧ९dᔊ၈ͣʧ९f݊ɓ၇ࠠ
ࠅ
ٙ
ߤ
Ϊ
ɿf
1979
ϋකնΤfจ
ܠ
݊ͣ
ߤ
ၾͣ
ߤ
ʘ
ගٙదʧ
ي
ሯf͍όնΤٙͣʧ९dՉ
cDNA
ਿΪٙ
IL-2
secretion
TH cell
T cell
B
cell
stimulation
of division
stimulation
of division and IFN gamma
release (and other mediators)
Increase in NK
Cell activity
NK
Activation
Monocyle
ତ
IL-33
̙ঐϞп
ط
ᐕ໘ৗʷसdɰ݊ɓ
ۆ
˿ɛࣈኧٙऊࢹfɛ
ࡁ
࿁ͣʧ९ᒱ್ˢ༰
ࠤ
͛dШ࿁е
ޥ
̌ঐ
ݵݵ੬੬ۍ
ᆀ༸dࣿʔٝе
ޥ
̌ঐٙ
ܝߠ
dͣʧ९வ
ࡈ
̌ЅྼၾϞଓf
專題探索
簡志瀚 Kan Chi Hon
